Renal fibrosis is the common pathological hallmark of progressive chronic kidney disease
(CKD) with diverse aetiologies. Recent researches have highlighted the critical role of …

The high renal oxygen (O2) demand is associated primarily with tubular O2 consumption
(Qo2) necessary for solute reabsorption. Increasing O2 delivery relative to demand via …

Previous studies have demonstrated intrarenal hypoxia in patients with diabetes. Hypoxia-
inducible factor (HIF)-1 plays an important role in hypoxia-induced tubulointerstitial fibrosis …

Mitochondrial oxidative damage is a basic mechanism of aging, and multiple studies
demonstrate that this process is attenuated by calorie restriction (CR). However, the …

Dapagliflozin, a new type of drug used to treat diabetes mellitus (DM), is a sodium/glucose
cotransporter 2 (SGLT2) inhibitor. Although some studies showed that SGLT2 inhibition …

Background: Anemia, a common complication of chronic kidney disease (CKD), has
previously been attributed primarily to decreased production of erythropoietin. More recently …

Although it is known that the expression and activity of sirtuin 1 (Sirt1) decrease in the aged
kidney, the role of interaction between Sirt1 and hypoxia‐inducible factor (HIF)‐1α is largely …

Abstract Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent
deacetylase belonging to class III histone deacetylases. Previous studies have shown that …

Tubulointerstitial hypoxia and peritubular capillary rarefaction are typical features of chronic
progressive renal disease. In response to low oxygen supply, hypoxia-inducible factors …

High glucose evokes a variety of signals in mesangial cells that alter cellular functions
responsible for the development of diabetic glomerulopathy. The hypoxia-inducible factor-1α …