[HTML][HTML] Therapeutic strategies against bacterial biofilms

Y Bi, G Xia, C Shi, J Wan, L Liu, Y Chen, Y Wu… - Fundamental …, 2021 - Elsevier
The emergence of multi-drug resistance makes bacterial infection a major threat to public
health and economy. The formation of bacterial biofilms is one of the main reasons of …

The role of coagulase-negative staphylococci biofilms on late-onset sepsis: current challenges and emerging diagnostics and therapies

A França - Antibiotics, 2023 - mdpi.com
Infections are one of the most significant complications of neonates, especially those born
preterm, with sepsis as one of the principal causes of mortality. Coagulase-negative …

Heat shock potentiates aminoglycosides against gram-negative bacteria by enhancing antibiotic uptake, protein aggregation, and ROS

B Lv, X Huang, C Lijia, Y Ma, M Bian… - Proceedings of the …, 2023 - National Acad Sciences
The potentiation of antibiotics is a promising strategy for combatting antibiotic-
resistant/tolerant bacteria. Herein, we report that a 5-min sublethal heat shock enhances the …

Environmental, mechanistic and evolutionary landscape of antibiotic persistence

C Bollen, E Louwagie, N Verstraeten, J Michiels… - EMBO …, 2023 - embopress.org
Recalcitrant infections pose a serious challenge by prolonging antibiotic therapies and
contributing to the spread of antibiotic resistance, thereby threatening the successful …

A mini-review: environmental and metabolic factors affecting aminoglycoside efficacy

CM Webster, M Shepherd - World Journal of Microbiology and …, 2023 - Springer
Following the discovery of streptomycin from Streptomyces griseus in the 1940s by Selman
Waksman and colleagues, aminoglycosides were first used to treat tuberculosis and then …

The in vitro and in vivo antibacterial activities of uniflorous honey from a medicinal plant, Scrophularia ningpoensis Hemsl., and characterization of its chemical profile …

T Lin, L Huang, N Cheng, Y Wang, Z Ning… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance According to the Compendium of Materia Medica, honey
has been used as a traditional medicine in treatment against mucositis, tinea, hemorrhoids …

Vibrio splendidus persister cells induced by host coelomic fluids show a similar phenotype to antibiotic‐induced counterparts

Y Li, TK Wood, W Zhang, C Li - Environmental microbiology, 2021 - Wiley Online Library
Persister cells are dormant variants of regular cells that are multidrug tolerant and have
heterogeneous phenotypes; these cells are a potential threat to hosts because they can …

n-Butanol Potentiates Subinhibitory Aminoglycosides against Bacterial Persisters and Multidrug-Resistant MRSA by Rapidly Enhancing Antibiotic Uptake

B Lv, M Bian, X Huang, F Sun, Y Gao… - ACS Infectious …, 2022 - ACS Publications
Potentiation of traditional antibiotics is of significance for combating antibiotic-resistant
bacteria that have become a severe threat to human and animal health. Here, we report that …

Escherichia coli cryptic prophages sense nutrients to influence persister cell resuscitation

S Song, JS Kim, R Yamasaki, S Oh… - Environmental …, 2021 - Wiley Online Library
Cryptic prophages are not genomic junk but instead enable cells to combat myriad stresses
as an active stress response. How these phage fossils affect persister cell resuscitation has …

[PDF][PDF] Are we really studying persister cells?

S Song, TK Wood - Environmental Microbiology Reports, 2021 - sites.psu.edu
Although persistence may be the most prevalent growth state for prokaryotes, since almost
all bacteria and archaeal cells are starving, the persister field is muddled. This has occurred …