Molecular pharmacology of VEGF-A isoforms: binding and signalling at VEGFR2
Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …
Design principles for therapeutic angiogenic materials
Despite extensive research, pro-angiogenic drugs have failed to translate clinically, and
therapeutic angiogenesis, which has potential in the treatment of various cardiovascular …
therapeutic angiogenesis, which has potential in the treatment of various cardiovascular …
VEGF regulates local inhibitory complement proteins in the eye and kidney
Outer retinal and renal glomerular functions rely on specialized vasculature maintained by
VEGF that is produced by neighboring epithelial cells, the retinal pigment epithelium (RPE) …
VEGF that is produced by neighboring epithelial cells, the retinal pigment epithelium (RPE) …
VEGFR-2 conformational switch in response to ligand binding
S Sarabipour, K Ballmer-Hofer, K Hristova - Elife, 2016 - elifesciences.org
VEGFR-2 is the primary regulator of angiogenesis, the development of new blood vessels
from pre-existing ones. VEGFR-2 has been hypothesized to be monomeric in the absence of …
from pre-existing ones. VEGFR-2 has been hypothesized to be monomeric in the absence of …
TKI-resistant renal cancer secretes low-level exosomal miR-549a to induce vascular permeability and angiogenesis to promote tumor metastasis
Z Xuan, C Chen, W Tang, S Ye, J Zheng… - Frontiers in cell and …, 2021 - frontiersin.org
Tyrosine kinase inhibitors (TKI)-resistant renal cancer is highly susceptible to metastasis,
and enhanced vascular permeability promotes the process of metastasis. To evaluate the …
and enhanced vascular permeability promotes the process of metastasis. To evaluate the …
The EphA2 receptor is activated through induction of distinct, ligand-dependent oligomeric structures
The EphA2 receptor tyrosine kinase is capable of activating multiple diverse signaling
pathways with roles in processes such as tissue homeostasis and cancer. EphA2 is known …
pathways with roles in processes such as tissue homeostasis and cancer. EphA2 is known …
RNF213 loss-of-function promotes angiogenesis of cerebral microvascular endothelial cells in a cellular state dependent manner
V Roy, A Brodeur, L Touzel Deschênes, N Dupré… - Cells, 2022 - mdpi.com
Enhanced and aberrant angiogenesis is one of the main features of Moyamoya disease
(MMD) pathogenesis. The ring finger protein 213 (RNF213) and the variant p. R4810K have …
(MMD) pathogenesis. The ring finger protein 213 (RNF213) and the variant p. R4810K have …
ADAMTS-1 and syndecan-4 intersect in the regulation of cell migration and angiogenesis
J Lambert, K Makin, S Akbareian… - Journal of cell …, 2020 - journals.biologists.com
ABSTRACT ADAMTS-1 is an extracellular protease with critical roles in organogenesis and
angiogenesis. Here we demonstrate a functional convergence of ADAMTS-1 and the …
angiogenesis. Here we demonstrate a functional convergence of ADAMTS-1 and the …
Multi-scale modeling in clinical oncology: opportunities and barriers to success
Hierarchical processes spanning several orders of magnitude of both space and time
underlie nearly all cancers. Multi-scale statistical, mathematical, and computational …
underlie nearly all cancers. Multi-scale statistical, mathematical, and computational …
VEGFR1 promotes cell migration and proliferation through PLCγ and PI3K pathways
JC Weddell, S Chen, PI Imoukhuede - NPJ systems biology and …, 2017 - nature.com
The ability to control vascular endothelial growth factor (VEGF) signaling offers promising
therapeutic potential for vascular diseases and cancer. Despite this promise, VEGF-targeted …
therapeutic potential for vascular diseases and cancer. Despite this promise, VEGF-targeted …