Acute coronary syndromes

BA Bergmark, N Mathenge, PA Merlini… - The Lancet, 2022 - thelancet.com
Although substantial progress has been made in the diagnosis and treatment of acute
coronary syndromes, cardiovascular disease remains the leading cause of death globally …

[HTML][HTML] The role of inflammation in cardiovascular disease

MY Henein, S Vancheri, G Longo… - International journal of …, 2022 - mdpi.com
Atherosclerosis is a chronic inflammatory disease, in which the immune system has a
prominent role in its development and progression. Inflammation-induced endothelial …

Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities

LA Bienvenu, J Noonan, X Wang… - Cardiovascular …, 2020 - academic.oup.com
The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
infection is a critical concern of the coronavirus disease 2019 (COVID-19) pandemic …

Targeting the NLRP3 inflammasome in cardiovascular diseases

S Toldo, E Mezzaroma, LF Buckley, N Potere… - Pharmacology & …, 2022 - Elsevier
The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …

Colchicine in cardiovascular disease: in-depth review

SG Deftereos, FJ Beerkens, B Shah, G Giannopoulos… - Circulation, 2022 - Am Heart Assoc
Inflammation plays a prominent role in the development of atherosclerosis and other
cardiovascular diseases, and anti-inflammatory agents may improve cardiovascular …

Macrophages in cardiac remodelling after myocardial infarction

J Yap, J Irei, J Lozano-Gerona, S Vanapruks… - Nature Reviews …, 2023 - nature.com
Myocardial infarction (MI), as a result of thrombosis or vascular occlusion, is the most
prevalent cause of morbidity and mortality among all cardiovascular diseases. The …

Efficacy and safety of low-dose colchicine in patients with coronary disease: a systematic review and meta-analysis of randomized trials

ATL Fiolet, TSJ Opstal, A Mosterd… - European Heart …, 2021 - academic.oup.com
Aims Recent randomized trials demonstrated a benefit of low-dose colchicine added to
guideline-based treatment in patients with recent myocardial infarction or chronic coronary …

Colchicine and the heart

M Imazio, M Nidorf - European Heart Journal, 2021 - academic.oup.com
Colchicine is a unique, sophisticated anti-inflammatory agent that has been used for
decades for the prevention of acute inflammatory flares in gout and familial Mediterranean …

The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases

S Toldo, A Abbate - Nature Reviews Cardiology, 2024 - nature.com
An intense, stereotyped inflammatory response occurs in response to ischaemic and non-
ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …

Effect of colchicine on myocardial injury in acute myocardial infarction

N Mewton, F Roubille, D Bresson, C Prieur, C Bouleti… - Circulation, 2021 - Am Heart Assoc
Background: Inflammation is a key factor of myocardial damage in reperfused ST-segment–
elevation myocardial infarction. We hypothesized that colchicine, a potent anti-inflammatory …