Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Obesity and ageing place a tremendous strain on the global healthcare system. Age-related
sarcopenia is characterized by decreased muscular strength, decreased muscle quantity …

Exercise represents a major challenge to whole-body homeostasis provoking widespread
perturbations in numerous cells, tissues, and organs that are caused by or are a response to …

Preservation of aerobic fitness and skeletal muscle strength through exercise training can
ameliorate metabolic dysfunction and prevent chronic disease. These benefits are mediated …

The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a
variety of environmental cues to regulate organismal growth and homeostasis. The pathway …

Specificity is a core principle of exercise training to promote the desired adaptations for
maximising athletic performance. The principle of specificity of adaptation is underpinned by …

Regular exercise has multi-system anti-aging effects. Here we summarize how exercise
impacts the major hallmarks of aging. We propose that, besides searching for novel …

Prolonged periods of skeletal muscle inactivity or mechanical unloading (bed rest, hindlimb
unloading, immobilization, spaceflight and reduced step) can result in a significant loss of …

The currently accepted amount of protein required to achieve maximal stimulation of
myofibrillar protein synthesis (MPS) following resistance exercise is 20–25 g. However, the …

Very few sports use only endurance or strength. Outside of running long distances on a flat
surface and power-lifting, practically all sports require some combination of endurance and …