[HTML][HTML] Evaluating the promise of inclusion of African ancestry populations in genomics

AR Bentley, SL Callier, CN Rotimi - NPJ genomic medicine, 2020 - nature.com
The lack of representation of diverse ancestral backgrounds in genomic research is well-
known, and the resultant scientific and ethical limitations are becoming increasingly …

[HTML][HTML] Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases

J Alvar, F Alves, B Bucheton, L Burrows… - Seminars in …, 2020 - Springer
Progress has been made in the control or elimination of tropical diseases, with a significant
reduction of incidence. However, there is a risk of re-emergence if the factors fueling …

Synthesis and structure-activity relationship studies of cruzain and rhodesain inhibitors

DA Rocha, EB Silva, IS Fortes, MS Lopes… - European Journal of …, 2018 - Elsevier
Abstract Chagas disease and Human African trypanosomiasis (HAT) are important public
health issues in Latin American and sub-Saharan African countries, respectively, and are …

The role of HLA‐G in parasitic diseases

A Sabbagh, P Sonon, I Sadissou, CT Mendes‐Junior… - Hla, 2018 - Wiley Online Library
Little attention has been devoted to the role of HLA‐G gene and molecule on parasitic
disorders, and the available studies have focused on malaria, African and American …

[HTML][HTML] Immunomodulatory Potential of Non-Classical HLA-G in Infections including COVID-19 and Parasitic Diseases

S Rashidi, C Vieira, R Tuteja, R Mansouri… - Biomolecules, 2022 - mdpi.com
Human Leukocyte Antigen-G (HLA-G), a polymorphic non-classical HLA (HLA-Ib) with
immune-regulatory properties in cancers and infectious diseases, presents both membrane …

[PDF][PDF] The H3Africa Consortium: publication outputs of a pan-African genomics collaboration (2013 to 2020)

A Choudhury, D Sengupta, S Aron… - Africa, the Cradle of …, 2021 - library.oapen.org
Developing a complex collaborative program across multiple African countries,
characterized by a diversity of government models, laws, cultures and norms, resources and …

[HTML][HTML] No evidence for association between APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations

MP Kimuda, H Noyes, J Mulindwa… - PLoS neglected …, 2018 - journals.plos.org
Background Human African trypanosomiasis (HAT) manifests as an acute form caused by
Trypanosoma brucei rhodesiense (Tbr) and a chronic form caused by Trypanosoma brucei …

[HTML][HTML] DIA-based technology explores hub pathways and biomarkers of neurological recovery in ischemic stroke after rehabilitation

W Hu, P Li, N Zeng, S Tan - Frontiers in Neurology, 2023 - frontiersin.org
Objective Ischemic stroke (IS) is a common disease that causes severe and long-term
neurological disability in people worldwide. Although rehabilitation is indispensable to …

Inflammation following trypanosome infection and persistence in the skin

D Mabille, G Caljon - Current Opinion in Immunology, 2020 - Elsevier
Highlights•The skin is transformed from an initial barrier to a reservoir tissue.•Skin-dwelling
trypanosomes sustain transmission and complicate diagnosis.•Trypanosomes modulate and …

[HTML][HTML] Physiological and proteomic profiles of Trypanosoma brucei rhodesiense parasite isolated from suramin responsive and non-responsive HAT patients in …

CN Mutuku, R Bateta, MK Rono, JM Njunge… - International Journal for …, 2021 - Elsevier
Abstract Human African Trypanosomiasis (HAT) is a disease of major economic importance
in Sub-Saharan Africa. The HAT is caused by Trypanosoma brucei rhodesiense (Tbr) …