[HTML][HTML] Genome-wide association studies of brain imaging phenotypes in UK Biobank
The genetic architecture of brain structure and function is largely unknown. To investigate
this, we carried out genome-wide association studies of 3,144 functional and structural brain …
this, we carried out genome-wide association studies of 3,144 functional and structural brain …
Quantitative assessment of structural image quality
Data quality is increasingly recognized as one of the most important confounding factors in
brain imaging research. It is particularly important for studies of brain development, where …
brain imaging research. It is particularly important for studies of brain development, where …
Enhancing the informativeness and replicability of imaging genomics studies
Imaging genomics is a new field of investigation that seeks to gain insights into the impact of
human genetic variation on the structure, chemistry, and function of neural systems in health …
human genetic variation on the structure, chemistry, and function of neural systems in health …
A meta‐analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the …
Schizophrenia is associated with widespread alterations in subcortical brain structure. While
analytic methods have enabled more detailed morphometric characterization, findings are …
analytic methods have enabled more detailed morphometric characterization, findings are …
Structural brain abnormalities in youth with psychosis spectrum symptoms
Importance Structural brain abnormalities are prominent in psychotic disorders, including
schizophrenia. However, it is unclear when aberrations emerge in the disease process and …
schizophrenia. However, it is unclear when aberrations emerge in the disease process and …
[HTML][HTML] Heritability and reliability of automatically segmented human hippocampal formation subregions
The human hippocampal formation can be divided into a set of cytoarchitecturally and
functionally distinct subregions, involved in different aspects of memory formation …
functionally distinct subregions, involved in different aspects of memory formation …
Glutamate imaging (GluCEST) reveals lower brain GluCEST contrast in patients on the psychosis spectrum
Psychosis commonly develops in adolescence or early adulthood. Youths at clinical high
risk (CHR) for psychosis exhibit similar, subtle symptoms to those with schizophrenia (SZ) …
risk (CHR) for psychosis exhibit similar, subtle symptoms to those with schizophrenia (SZ) …
[HTML][HTML] The genetic architecture of human amygdala volumes and their overlap with common brain disorders
YN Ou, BS Wu, YJ Ge, Y Zhang, YC Jiang… - Translational …, 2023 - nature.com
The amygdala is a crucial interconnecting structure in the brain that performs several
regulatory functions, yet its genetic architectures and involvement in brain disorders remain …
regulatory functions, yet its genetic architectures and involvement in brain disorders remain …
[HTML][HTML] Multidimensional heritability analysis of neuroanatomical shape
In the dawning era of large-scale biomedical data, multidimensional phenotype vectors will
play an increasing role in examining the genetic underpinnings of brain features, behaviour …
play an increasing role in examining the genetic underpinnings of brain features, behaviour …
[HTML][HTML] Polygenic risk for schizophrenia and subcortical brain anatomy in the UK Biobank cohort
S Grama, I Willcocks, JJ Hubert, AF Pardiñas… - Translational …, 2020 - nature.com
Research has shown differences in subcortical brain volumes between participants with
schizophrenia and healthy controls. However, none of these differences have been found to …
schizophrenia and healthy controls. However, none of these differences have been found to …