Pathophysiology of pulmonary hypertension in acute lung injury

LC Price, DF McAuley, PS Marino… - … of Physiology-Lung …, 2012 - journals.physiology.org
Acute lung injury (ALI) and acute respiratory distress syndrome are characterized by protein
rich alveolar edema, reduced lung compliance, and acute severe hypoxemia. A degree of …

[PDF][PDF] BNP and NT-proBNP levels in patients with sepsis

N Li, Y Zhang, S Fan, J Xing… - Front Biosci (Landmark Ed), 2013 - article.imrpress.com
Sepsis is a severe complication of critically ill patients that is characterized by the systemic
inflammatory response syndrome (SIRS). The increased levels of B-type natriuretic peptide …

Nonventilatory strategies for patients with life-threatening 2009 H1N1 influenza and severe respiratory failure

LM Napolitano, PK Park, K Raghavendran… - Critical Care …, 2010 - journals.lww.com
Severe respiratory failure (including acute lung injury and acute respiratory distress
syndrome) caused by 2009 H1N1 influenza infection has been reported worldwide …

Acute lung injury and pulmonary vascular permeability: use of transgenic models

JC Parker - Comprehensive Physiology, 2011 - Wiley Online Library
Acute lung injury is a general term that describes injurious conditions that can range from
mild interstitial edema to massive inflammatory tissue destruction. This review will cover …

Radiographic lung density assessed by computed tomography is associated with extravascular lung water content

VV Kuzkov, EV Suborov, MY Kirov… - Acta …, 2010 - Wiley Online Library
Background: We hypothesized that in acute lung injury (ALI), the volume of pulmonary tissue
with aqueous density, as determined by spiral computed tomography (CT), is associated …

[HTML][HTML] Inhaled aerosolised recombinant human activated protein C ameliorates endotoxin-induced lung injury in anaesthetised sheep

K Waerhaug, VV Kuzkov, VN Kuklin, R Mortensen… - Critical Care, 2009 - Springer
Introduction We recently demonstrated that intravenously infused recombinant human
activated protein C (APC) attenuates ovine lipopolysaccharide (LPS)-induced lung injury. In …

Anaesthetic and cardiorespiratory effects of a constant‐rate infusion of alfaxalone in desflurane‐anaesthetised sheep

M del Mar Granados, JM Domínguez… - Veterinary …, 2012 - Wiley Online Library
A prospective, randomised, blinded controlled study was performed to determine the
anaesthetic and cardiorespiratory effects of a constant‐rate infusion (CRI) of alfaxalone in 12 …

Activated protein C attenuates acute lung injury and apoptosis in a hyperoxic animal model

AW Husari, A Khayat, H Awdeh, H Hatoum, M Nasser… - Shock, 2010 - journals.lww.com
Evidence suggests that activated protein C (APC) attenuates acute lung injury (ALI) through
antithrombotic and anti-inflammatory mechanisms. The aim of this study was to determine …

Nebulized anticoagulants limit coagulopathy but not inflammation in pseudomonas aeruginosa-induced pneumonia in rats

AD Cornet, JJ Hofstra, AP Vlaar, FE van den Boogaard… - Shock, 2011 - journals.lww.com
Disturbed alveolar fibrin turnover is a characteristic feature of pneumonia. Inhibitors of
coagulation could exert lung-protective effects via anticoagulant (inhibiting fibrin deposition) …

[HTML][HTML] Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic shock

MO Maybauer, DM Maybauer, JF Fraser, C Szabo… - Critical Care, 2010 - Springer
Introduction This prospective, randomized, controlled, experimental animal study looks at
the effects of recombinant human activated protein C (rhAPC) on global hemodynamics and …