Brain mechanisms underlying neuropsychiatric symptoms in Alzheimer's disease: a systematic review of symptom-general and–specific lesion patterns

Y Chen, M Dang, Z Zhang - Molecular Neurodegeneration, 2021 - Springer
Neuropsychiatric symptoms (NPSs) are common in patients with Alzheimer's disease (AD)
and are associated with accelerated cognitive impairment and earlier deaths. This review …

Depression in dementia: epidemiology, mechanisms, and treatment

D Enache, B Winblad, D Aarsland - Current opinion in psychiatry, 2011 - journals.lww.com
Depression in dementia: epidemiology, mechanisms, and treatm... : Current Opinion in
Psychiatry Depression in dementia: epidemiology, mechanisms, and treatment : Current …

The serotonergic system in ageing and Alzheimer's disease

JJ Rodríguez, HN Noristani, A Verkhratsky - Progress in neurobiology, 2012 - Elsevier
Alzheimer's disease (AD) is one of the major neurodegenerative diseases that deteriorates
cognitive functions and primarily affects associated brain regions involved in learning and …

Behavioral and psychological symptoms in Alzheimer's disease

XL Li, N Hu, MS Tan, JT Yu… - BioMed research …, 2014 - Wiley Online Library
Neuropsychiatric symptoms (NPS) such as depression, apathy, aggression, and psychosis
are now recognized as core features of Alzheimer's disease (AD), and there is a general …

[HTML][HTML] Relationships between mitochondrial dysfunction and neurotransmission failure in Alzheimer's disease

KY Wong, J Roy, ML Fung, BC Heng, C Zhang… - Aging and …, 2020 - ncbi.nlm.nih.gov
Besides extracellular deposition of amyloid beta and formation of phosphorylated tau in the
brains of patients with Alzheimer's disease (AD), the pathogenesis of AD is also thought to …

Principles and management of neuropsychiatric symptoms in Alzheimer's dementia

MA Nowrangi, CG Lyketsos, PB Rosenberg - Alzheimer's research & …, 2015 - Springer
Neuropsychiatric symptoms of Alzheimer's disease (NPS-AD) are highly prevalent and lead
to poor medical and functional outcomes. In spite of the burdensome nature of NPS-AD, we …

[HTML][HTML] Apathy as a treatment target in Alzheimer's disease: implications for clinical trials

ME Mortby, L Adler, L Agüera-Ortiz, DR Bateman… - The American Journal of …, 2022 - Elsevier
Apathy is one of the most prevalent, stable and persistent neuropsychiatric symptom across
the neurocognitive disorders spectrum. Recent advances in understanding of …

Mild cognitive impairment and risk of depression and anxiety: A population-based study

SS Mirza, MA Ikram, D Bos, R Mihaescu, A Hofman… - Alzheimer's & …, 2017 - Elsevier
Introduction Many people with mild cognitive impairment (MCI) suffer from concomitant
depression or anxiety. Whether MCI increases the risk of future depression or anxiety is …

Serotonergic therapies for cognitive symptoms in Alzheimer's disease: rationale and current status

MJ Ramirez, MKP Lai, RM Tordera, PT Francis - Drugs, 2014 - Springer
Alzheimer's disease (AD) is the most common cause of dementia in elderly people.
Research focused on identifying compounds that restore cognition and memory in AD …

Monoaminergic neurotransmitter alterations in postmortem brain regions of depressed and aggressive patients with Alzheimer's disease

Y Vermeiren, D Van Dam, T Aerts, S Engelborghs… - Neurobiology of …, 2014 - Elsevier
Depression and aggression in Alzheimer's disease (AD) are 2 of the most severe and
prominent neuropsychiatric symptoms (NPS). Altered monoaminergic neurotransmitter …