Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …
[HTML][HTML] Selective autophagy of intracellular organelles: recent research advances
Macroautophagy (hereafter called autophagy) is a highly conserved physiological process
that degrades over-abundant or damaged organelles, large protein aggregates and …
that degrades over-abundant or damaged organelles, large protein aggregates and …
[HTML][HTML] The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”
Abstract Purpose Novel Coronavirus disease 2019 (COVID-19), is an acute respiratory
distress syndrome (ARDS), which is emerged in Wuhan, and recently become worldwide …
distress syndrome (ARDS), which is emerged in Wuhan, and recently become worldwide …
[PDF][PDF] Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's disease
L Traxler, JR Herdy, D Stefanoni, S Eichhorner… - Cell Metabolism, 2022 - cell.com
The drivers of sporadic Alzheimer's disease (AD) remain incompletely understood. Utilizing
directly converted induced neurons (iNs) from AD-patient-derived fibroblasts, we identified a …
directly converted induced neurons (iNs) from AD-patient-derived fibroblasts, we identified a …
[HTML][HTML] Selective autophagy receptor p62/SQSTM1, a pivotal player in stress and aging
AV Kumar, J Mills, LR Lapierre - Frontiers in cell and developmental …, 2022 - frontiersin.org
Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads
to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by …
to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by …
Mitophagy in degenerative joint diseases
K Sun, X Jing, J Guo, X Yao, F Guo - Autophagy, 2021 - Taylor & Francis
Mitochondrial dysfunction is involved in aging and multiple degenerative diseases, including
intervertebral disc degeneration (IVDD) and osteoarthritis (OA). Thus, the maintenance of …
intervertebral disc degeneration (IVDD) and osteoarthritis (OA). Thus, the maintenance of …
Signaling by cGAS–STING in neurodegeneration, neuroinflammation, and aging
Recognition of foreign or misplaced nucleic acids is one of the principal modes by which the
immune system detects pathogenic entities. When cytosolic DNA is sensed, a signal is …
immune system detects pathogenic entities. When cytosolic DNA is sensed, a signal is …
[HTML][HTML] Mitochondria in cancer
D Grasso, LX Zampieri, T Capelôa, JA Van de Velde… - Cell stress, 2020 - ncbi.nlm.nih.gov
The rediscovery and reinterpretation of the Warburg effect in the year 2000 occulted for
almost a decade the key functions exerted by mitochondria in cancer cells. Until recent …
almost a decade the key functions exerted by mitochondria in cancer cells. Until recent …
[HTML][HTML] Glaucomatous optic neuropathy: Mitochondrial dynamics, dysfunction and protection in retinal ganglion cells
Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by a
slow, progressive, and multifactorial degeneration of retinal ganglion cells (RGCs) and their …
slow, progressive, and multifactorial degeneration of retinal ganglion cells (RGCs) and their …
Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: An update on current advances and …
Neurodegenerative diseases (NDs) such as Alzheimer disease (AD), Parkinson disease
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …