Dexamethasone-induced acute excitotoxic cell death in the developing brain

DA Lanshakov, EV Sukhareva, TS Kalinina… - Neurobiology of …, 2016 - Elsevier
There is substantial evidence that the use of glucocorticoids in neonates is associated with
an increased risk of neurodevelopmental disorders. However, it remains unclear how …

Neurochemical consequences of kainate-induced toxicity in brain: involvement of arachidonic acid release and prevention of toxicity by phospholipase A2 inhibitors

AA Farooqui, WY Ong, XR Lu, B Halliwell… - Brain Research …, 2001 - Elsevier
In kainate-induced neurotoxicity, the stimulation of kainate receptors results in the activation
of phospholipase A2 and a rapid release of arachidonic acid from neural membrane …

Stress and the etiopathogenesis of Alzheimer's disease and depression

I Sotiropoulos, JM Silva, P Gomes, N Sousa… - Tau biology, 2019 - Springer
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder with a complex
physiopathology whose initiators are poorly defined. Accumulating clinical and experimental …

The corticosterone synthesis inhibitor metyrapone prevents hypoxia/ischemia-induced loss of synaptic function in the rat hippocampus

HJ Krugers, S Maslam, J Korf, M Joëls - Stroke, 2000 - Am Heart Assoc
Background and Purpose—Ischemia is accompanied by abundant corticosterone secretion,
which could potentially exacerbate brain damage via activation of glucocorticoid receptors …

Kainate-induced genes in the hippocampus: lessons from expression patterns

S Zagulska-Szymczak, RK Filipkowski… - Neurochemistry …, 2001 - Elsevier
Kainate, the analog of the excitatory amino acid l-glutamate, upon binding to non-NMDA
glutamate receptors, causes depolarization of neurons followed by severe status epilepticus …

[HTML][HTML] Relevance of chronic stress and the two faces of microglia in Parkinson's disease

AJ Herrera, AM Espinosa-Oliva… - Frontiers in cellular …, 2015 - frontiersin.org
This review is aimed to highlight the importance of stress and glucocorticoids (GCs) in
modulating the inflammatory response of brain microglia and hence its potential involvement …

Effects of mineralocorticoid and glucocorticoid receptors on long-term potentiation in the CA3 hippocampal field

C Pavlides, BS McEwen - Brain research, 1999 - Elsevier
We have previously shown that the two types of adrenal steroid receptors, mineralocorticoid
(MR) and glucocorticoid (GR) produce opposite effects on long-term potentiation (LTP) in the …

Attenuation of abnormal glutamate release in zinc deficiency by zinc and Yokukansan

A Takeda, H Tamano, H Itoh, N Oku - Neurochemistry international, 2008 - Elsevier
The mechanism of the abnormal increase in extracellular glutamate concentration in the
hippocampus induced with 100mM KCl in zinc deficiency is unknown. In the present study …

Corticosterone enhances kainic acid‐induced calcium elevation in cultured hippocampal neurons

EM Elliott, RM Sapolsky - Journal of neurochemistry, 1992 - Wiley Online Library
Corticosterone, a steroid secreted during stress, increases hippocampal neuronal
vulnerability to excitotoxins, hypoxia‐ischemia, and antimetabolites. Energy …

Behavior in the forced swim test and neurochemical changes in the hippocampus in young rats after 2-week zinc deprivation

H Tamano, F Kan, M Kawamura, N Oku… - Neurochemistry …, 2009 - Elsevier
Abnormal behavior in zinc deficiency and its cause are poorly understood. In the present
paper, behavior in the forced swim test and neurochemical changes in the brain associated …