Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …

Simple Summary Melanoma is a dreadful type of skin cancer with a poor response to
therapy. Senescent cells have been found to accumulate with age and may contribute to the …

The potential of immune checkpoint inhibitors (ICI) may be limited in situations where
immune cell fitness is impaired. Here, we show that the efficacy of cancer immunotherapies …

Oxidative stress refers to the imbalance between the production of reactive oxygen species
(ROS) and the endogenous antioxidant defense system. Its involvement in cell senescence …

Radiotherapy induces a type I interferon–mediated (T1IFN-mediated) antitumoral immune
response that we hypothesized could be potentiated by a first-in-class ataxia telangiectasia …

Immune checkpoint inhibitors (ICIs) are employed in immunotherapeutic applications for
patients with weakened immune systems and can improve the ability of T cells to kill cancer …

Immune checkpoint blockade (ICB) therapy can improve the survival of cancer patients with
a high tumor mutation burden (TMB-H) or deficiency in DNA mismatch repair (dMMR) in their …

Mesenchymal stromal cells (MSCs) together with malignant cells present in the tumor
microenvironment (TME), participate in the suppression of the antitumor immune response …

Numerous studies have demonstrated that regulatory T (Treg) cells play an important role in
the tumour microenvironment (TME). The aim of this study was to investigate whether …

Lung adenocarcinoma (LUAD), the most common histological type in lung cancer, is one of
leading cancers with considerable morbidity/mortality worldwide. Treating LUAD remains an …