Objectives. This study sought to examine the hemodynamic and autonomic dose response
to digoxin. Background. Previous studies have demonstrated an increase in contractility and …

Background Digitalis glycosides have been in clinical use for the treatment of heart failure
(HF) for longer than 200 years. In recent years, several trials have been conducted to …

Background Growth hormone has been shown to increase maximum isometric active force
of the left ventricular papillary muscle of rats in vitro. Administration of growth hormone …

Abstract The Studies of Left Ventricular Dysfunction (SOLVD) trials were designed to
evaluate the effects of enalapril on long-term mortality in patients with severe left ventricular …

Heart failure (HF) is a complex clinical syndrome resulting from any structural or functional
cardiac disorder impairing the ability of the ventricles to fill with or eject blood. The approach …

Evidence-based medicine is an evolutionary process, intended to foster and disseminate the
best practice guidelines from an ongoing critical analysis of available data. An …

The importance of left ventricular (LV) shape in determining exercise capacity was assessed
in 40 male patients with LV dysfunction after anterior acute myocardial infarction (AMI) …

Objectives. The aim of this study was to assess the efficacy of flosequinan in chronic heart
failure. Background. Flosequinan is a new vasodilator drug that acts by interfering with the …

Several large well-designed clinical trials have shown that the use of diuretics is beneficial
in patients with hypertension. However, similarly robust data regarding their role in chronic …

Background Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a severely
debilitating disease of unknown pathogenesis consisting of a variety of symptoms including …