Positron emission tomography (PET) uses radioactive tracers and enables the functional
imaging of several metabolic processes, blood flow measurements, regional chemical …

Purpose A limit on developing new treatments for a number of central nervous system (CNS)
disorders has been the inadequate understanding of the in vivo pathophysiology underlying …

Mouse models of Alzheimer's disease (AD) are valuable but do not fully recapitulate human
AD pathology, such as spontaneous Tau fibril accumulation and neuronal loss …

Cholinergic receptors represent a promising class of diagnostic and therapeutic targets due
to their significant involvement in cognitive decline associated with neurological disorders …

Purpose Using the α7-nAChR radiotracer,[18 F] ASEM, we present the first successful
human positron emission tomography (PET) studies. Rodent occupancy with three clinically …

Amyloid-β (Aβ) accumulation and tauopathy are considered the pathological hallmarks of
Alzheimer's disease (AD), but attenuation in choline signaling, including decreased nicotinic …

Background The α7 nicotinic acetylcholine receptor increasingly has been implicated in
normal brain physiology, as well as in neuropsychiatric disorders. The highly cortical …

The α7-nicotinic cholinergic receptor (α7-nAChR) is a key mediator of brain communication
and has been implicated in a wide variety of central nervous system disorders. None of the …

Purpose The α 7 nicotinic acetylcholine receptor (nAChR) is implicated in many
neuropsychiatric disorders, making it an important target for positron emission tomography …

The first sulfhydryl-directed iridium-catalyzed C–H/diazo coupling and tandem annulation of
naphthalene-1-thiols has been developed. The framework of naphtho [1, 8-bc] thiopyrans …