Well-established in the field of bioelectronic medicine, Spinal Cord Stimulation (SCS) offers
an implantable, non-pharmacologic treatment for patients with intractable chronic pain …

There has been recent evidence showing the correlation between neuroinflammation owing
to the chemokine–cytokine network and neuropathic pain. Chemokines and cytokines are …

Introduction The primary objective of this paper is to (1) provide a summary of human studies
that have used brain derived neurotrophic factor (BDNF) as a biomarker,(2) review animal …

Chronic pain is sustained, in part, through the intricate process of central sensitization (CS),
marked by maladaptive neuroplasticity and neuronal hyperexcitability within central pain …

Background In neuropathic pain following peripheral nerve injury, microglia are rapidly
activated and accumulated in the spinal cord. Physical exercise can alleviate neuropathic …

Neuropathic pain is a common clinical condition. Current treatments are often inadequate,
ineffective, or produce potentially severe adverse effects. Understanding the mechanisms …

Peripheral nerve injuries result in loss of motor, sensory and autonomic functions of the
denervated limb, but are also accompanied by positive symptoms, such as hyperreflexia …

Neuropathic pain (NP) is a frequent condition caused by a lesion in, or disease of, the
central or peripheral somatosensory nervous system and is associated with excessive …

Recent investigation of microRNAs on chronic pain has developed a breakthrough in
neuropathic pain management. In the present study, decreased expression of miR-30a-3p …

Neuropathic pain (NP) is caused by direct or indirect damage to the nervous system and is a
common symptom of many diseases. The mechanisms underlying the onset and persistence …