Aging is a major cause of many degenerative diseases. The most intuitive consequence of
aging is mainly manifested on the skin, resulting in cumulative changes in skin structure …

Skin aging is one of the most evident signs of human aging. Modification of the skin during
the life span is characterized by fine lines and wrinkling, loss of elasticity and volume, laxity …

Fibroblasts are the major mesenchymal cell type in connective tissue and deposit the
collagen and elastic fibres of the extracellular matrix (ECM). Even within a single tissue …

As global life expectancy continues to rise, we are challenged with maintaining health into
old age. One strategy is to target the chronic low-level inflammation associated with aging …

With worldwide expansion of the aging population, research on age-related pathologies is
receiving growing interest. In this review, we discuss current knowledge regarding the …

The skin protects mammals from insults, infection and dehydration and enables
thermoregulation and sensory perception. Various skin-resident cells carry out these diverse …

Skin is the largest human organ. Skin continually reconstructs itself to ensure its viability,
integrity, and ability to provide protection for the body. Some areas of skin are continuously …

All multicellular organisms undergo a decline in tissue and organ function as they age. An
attractive theory is that a loss in stem cell number and/or activity over time causes this …

INTRODUCTION During aging, most organs in mammals become smaller (miniaturize) or
thinner, and their functions and regenerative capability also decline. Histologically, tissue …

Fibroblasts are found in most tissues, yet they remain poorly characterised. Different
fibroblast subpopulations with distinct functions have been identified in the skin. This …