In the central nervous system (CNS), astrocytes form networks interconnected by gap
junctions made from connexins of the subtypes Cx30 and Cx43. When unopposed by an …

Intercellular calcium (Ca2+) waves (ICWs) represent the propagation of increases in
intracellular Ca2+ through a syncytium of cells and appear to be a fundamental mechanism …

Upon its release from injured cells, such as infected, transformed, inflamed, or necrotic cells,
extracellular adenosine-5ʹ-triphosphate (ATP) acts as a danger signal that recruits …

Functional interaction between neurons and glia is an exciting field that has expanded
tremendously during the past decade. Such partnership has multiple impacts on neuronal …

Ferroptosis is an oxidative and iron-dependent form of regulated cell death (RCD) recently
described in eukaryotic organisms like animals, plants, and parasites. Here, we report that a …

Abstract Mitochondrial connexin 43 (Cx43) plays a key role in cardiac cytoprotection caused
by repeated exposure to short periods of non-lethal ischemia/reperfusion, a condition known …

Cardiac connexin-43 (Cx43) creates gap junction channels (GJCs) at intercellular contacts
and hemi-channels (HCs) at the peri-junctional plasma membrane and sarcolemmal …

Oxidative stress is a major risk factor that causes osteocyte cell death and bone loss. Prior
studies primarily focus on the function of cell surface expressed Cx43 channels. Here, we …

Background Endothelial progenitor cell (EPC) differentiation is considered crucial for
vascular repair. Vascular endothelial growth factor (VEGF) induces EPC differentiation, but …

Gap junctions are unique membrane channels that play a significant role in intercellular
communication in the developing and mature central nervous system (CNS). These …