Monosodium glutamate (MSG) is an umami substance widely used as flavor enhancer.
Although it is generally recognized as being safe by food safety regulatory agencies, several …

Chloride is the principal anion of the extracellular fluid and vital for both serum
electroneutrality and acid-base homeostasis. The aim of this review is to investigate the …

Following a request from the European Commission, the EFSA Panel on Nutrition, Novel
Foods and Food Allergens (NDA) derived dietary reference values (DRV s) for sodium …

Abstract Purpose of Review Excess sodium from dietary salt (NaCl) is linked to elevations in
blood pressure (BP). However, salt sensitivity of BP varies widely between individuals and …

Acid‐sensing ion channels (ASICs) and the epithelial Na+ channel (ENaC) are both
members of the ENaC/degenerin family of amiloride‐sensitive Na+ channels. ASICs act as …

Acute kidney injury (AKI) is a major public health problem that complicates 10–40% of
hospital admissions. Importantly, AKI is independently associated with increased risk of …

Despite considerable advances in pharmacological treatments, hypertension remains a
major cause of premature morbidity and mortality worldwide since elevated blood pressure …

The specific role of the chloride anion (Cl−) as a signalling effector or second messenger
has been increasingly recognized in recent years. It could represent a key factor in the …

Imidazole is an essential heterocyclic building block for biological, optical, and electrical
fields. It has a unique bipolar configuration of two donor and acceptor N atoms apart via C2 …

Background Association studies have identified several biomarkers for blood pressure and
hypertension, but a thorough understanding of their mutual dependencies is lacking. By …