Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases …

Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …

Initiation and development of cancer depend on multiple factors that mutations in genes and
epigenetic level can be considered as important drivers. Epigenetic factors include a large …

Lung cancer (LC) is the most common cancer-related death globally, and many efforts have
been made to improve the patient care of LC patients, as well as the development of efficient …

With the development of nanotechnology, nanoparticles have emerged as a delivery carrier
for tumor drug therapy, which can improve the therapeutic effect by increasing the stability …

Simple Summary Mutations in the tumor suppressor p53 (p53) occur in~ 50% of human
cancers, the majority of which are missense mutations. Mutations in p53 not only impair the …

Small cell lung cancer (SCLC) is a type of neuroendocrine tumor with high malignancy and
poor prognosis. Besides the de novo SCLC, there is transformed SCLC, which has similar …

Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …

Testicular germ cell tumors (TGCTs) are the most common testicular neoplasms in
adolescents and young males. Understanding the genetic basis of TGCTs represents a …

Abstract Mouse double minute 2 (MDM2) is an E3 ubiquitin ligase which effectively
degrades tumor suppressor p53. In the past two decades, many MDM2 inhibitors that disrupt …