Objective To determine the contributions of angiogenesis to inflammation, joint damage, and
pain behavior in a rat meniscal transection model of osteoarthritis (OA). Methods OA was …

Introduction miR-146a is one of the first identified miRNAs expressed differentially in
osteoarthritis (OA) cartilage. However, the role it plays in OA pathogenesis is not clear. The …

Growing evidence from epidemiological studies suggests that osteoarthritis (OA) is linked to
atheromatous vascular disease. This hypothesis article proposes that OA, or at least OA …

Osteoarthritis (OA) is defined as a degenerative joint disease that can affect all tissues of the
joint, including the articular cartilage, subchondral bone, ligaments capsule, and synovial …

Osteoarthritis (OA) is a leading cause of disability, globally. Despite an emerging role for
synovial inflammation in OA pathogenesis, attempts to target inflammation therapeutically …

Objective We investigated the effects of celecoxib, diclofenac, and ibuprofen on the disease-
specific quality of life, synovial fluid cytokines and signal transduction pathways in …

Activation of an innate immune response is among the first lines of defense after tissue
injury. Restoring blood flow to the site of injured tissue is often a necessary prerequisite for …

Osteoarthritis (OA) has remained a prevalent public health problem worldwide over the past
decades. OA is a global challenge because its specific pathogenesis is unclear, and no …

Objective Structural changes of osteoarthritis (OA) may occur in the absence of pain. In this
study, we aimed to identify histopathologic features that are associated with symptomatic …

Macrophages belong to the innate immune system giving us protection against pathogens.
However it is known that they are also involved in rheumatic diseases. Activated …