[HTML][HTML] A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice
It has been proposed that two amino acid substitutions in the transcription factor FOXP2
have been positively selected during human evolution due to effects on aspects of speech …
have been positively selected during human evolution due to effects on aspects of speech …
The derived FOXP2 variant of modern humans was shared with Neandertals
Although many animals communicate vocally, no extant creature rivals modern humans in
language ability. Therefore, knowing when and under what evolutionary pressures our …
language ability. Therefore, knowing when and under what evolutionary pressures our …
Human-specific transcriptional regulation of CNS development genes by FOXP2
G Konopka, JM Bomar, K Winden, G Coppola… - Nature, 2009 - nature.com
The signalling pathways controlling both the evolution and development of language in the
human brain remain unknown. So far, the transcription factor FOXP2 (forkhead box P2) is …
human brain remain unknown. So far, the transcription factor FOXP2 (forkhead box P2) is …
Brain mechanisms of acoustic communication in humans and nonhuman primates: an evolutionary perspective
Any account of “what is special about the human brain”(Passingham 2008) must specify the
neural basis of our unique ability to produce speech and delineate how these remarkable …
neural basis of our unique ability to produce speech and delineate how these remarkable …
Incomplete and Inaccurate Vocal Imitation after Knockdown of FoxP2 in Songbird Basal Ganglia Nucleus Area X
S Haesler, C Rochefort, B Georgi, P Licznerski… - PLoS …, 2007 - journals.plos.org
The gene encoding the forkhead box transcription factor, FOXP2, is essential for developing
the full articulatory power of human language. Mutations of FOXP2 cause developmental …
the full articulatory power of human language. Mutations of FOXP2 cause developmental …
High-impact rare genetic variants in severe schizophrenia
Extreme phenotype sequencing has led to the identification of high-impact rare genetic
variants for many complex disorders but has not been applied to studies of severe …
variants for many complex disorders but has not been applied to studies of severe …
Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain
Forkhead-box protein P2 is a transcription factor that has been associated with intriguing
aspects of cognitive function in humans, non-human mammals, and song-learning birds …
aspects of cognitive function in humans, non-human mammals, and song-learning birds …
Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene
W Shu, JY Cho, Y Jiang, M Zhang… - Proceedings of the …, 2005 - National Acad Sciences
Neurobiology of speech and language has previously been studied in the KE family, in
which half of the members have severe impairment in both speech and language. The gene …
which half of the members have severe impairment in both speech and language. The gene …
Childhood apraxia of speech
American Speech-Language-Hearing Association - 2007 - ASHA
The goal of this technical report on childhood apraxia of speech (CAS) was to assemble
information about this challenging disorder that would be useful for caregivers, speech …
information about this challenging disorder that would be useful for caregivers, speech …
Genetic advances in the study of speech and language disorders
DF Newbury, AP Monaco - Neuron, 2010 - cell.com
Developmental speech and language disorders cover a wide range of childhood conditions
with overlapping but heterogeneous phenotypes and underlying etiologies. This …
with overlapping but heterogeneous phenotypes and underlying etiologies. This …