Most cases of serotonin toxicity are provoked by therapeutic doses of a combination of two
or more serotonergic drugs, defined as drugs affecting the serotonin neurotransmitter …

Drugs may cause serotonin toxicity by a number of different mechanisms including inhibition
of serotonin uptake and metabolism, increased serotonin synthesis and release, activation …

Serotonin syndrome is associated with use of certain street drugs, including
methamphetamine, cocaine, and ecstasy. We describe a case of a woman who developed …

Transplantation provides life-saving therapy to critically ill patients with end-stage organ
failure. We found that the specialized knowledge of mental health clinicians and physicians …

Abstract The serotonin (5-hydroxtryptamine, 5-HT) system plays a role in analgesia and
emesis. The aim of this study was to test whether opioids or ketamine inhibit the human 5-HT …

Serotonin syndrome is a syndrome identified by a triad of altered mental status,
neuromuscular overactivity, and autonomic instability caused by the overstimulation of …

Serotonin syndrome is thought to arise from serotonin excess. In many cases, symptoms are
mild and self-limiting. But serotonin syndrome can become life threatening, when …

Background Long-term opioid use is associated with dependency, addiction, and serious
adverse events. Although a framework to reduce inappropriate opioid prescribing exists …

A patient who manifested signs of serotonin syndrome during an intravenous anesthetic with
remifentanil and propofol is presented. The patient displayed lower extremity clonus …

The United States continues to be impacted by decades of an opioid misuse epidemic,
worsened by the COVID-19 pandemic and by the growing prevalence of highly potent …