Microglial cells: the main HIV-1 reservoir in the brain
C Wallet, M De Rovere, J Van Assche… - Frontiers in cellular …, 2019 - frontiersin.org
Despite efficient combination of the antiretroviral therapy (cART), which significantly
decreased mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been …
decreased mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been …
Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic
M Caskey, F Klein, MC Nussenzweig - Nature medicine, 2019 - nature.com
Combination anti-retroviral therapy (ART) has revolutionized the treatment and prevention of
HIV-1 infection. Taken daily, ART prevents and suppresses the infection. However, ART …
HIV-1 infection. Taken daily, ART prevents and suppresses the infection. However, ART …
Combination anti-HIV antibodies provide sustained virological suppression
MC Sneller, J Blazkova, JS Justement, V Shi… - Nature, 2022 - nature.com
Antiretroviral therapy is highly effective in suppressing human immunodeficiency virus (HIV).
However, eradication of the virus in individuals with HIV has not been possible to date …
However, eradication of the virus in individuals with HIV has not been possible to date …
Clonally expanded HIV-1 proviruses with 5′-leader defects can give rise to nonsuppressible residual viremia
Background Antiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below
the detection limit of clinical assays. However, some individuals experience persistent …
the detection limit of clinical assays. However, some individuals experience persistent …
HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy
Y Ganor, F Real, A Sennepin, CA Dutertre… - Nature …, 2019 - nature.com
Human immunodeficiency virus type 1 (HIV-1) eradication is prevented by the establishment
on infection of cellular HIV-1 reservoirs that are not fully characterized, especially in genital …
on infection of cellular HIV-1 reservoirs that are not fully characterized, especially in genital …
HIV persists throughout deep tissues with repopulation from multiple anatomical sources
BACKGROUND Understanding HIV dynamics across the human body is important for cure
efforts. This goal has been hampered by technical difficulties and the challenge of obtaining …
efforts. This goal has been hampered by technical difficulties and the challenge of obtaining …
Evolutionary causes and consequences of bacterial antibiotic persistence
Antibiotic treatment failure is of growing concern. Genetically encoded resistance is key in
driving this process. However, there is increasing evidence that bacterial antibiotic …
driving this process. However, there is increasing evidence that bacterial antibiotic …
Current status of latency reversing agents facing the heterogeneity of HIV-1 cellular and tissue reservoirs
One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells
The persistence of CD4+ T cells carrying latent human immunodeficiency virus-1 (HIV-1)
proviruses is the main barrier to a cure. New therapeutics to enhance HIV-1-specific immune …
proviruses is the main barrier to a cure. New therapeutics to enhance HIV-1-specific immune …
Mechanistic modeling of SARS‐CoV‐2 and other infectious diseases and the effects of therapeutics
AS Perelson, R Ke - Clinical Pharmacology & Therapeutics, 2021 - Wiley Online Library
Modern viral kinetic modeling and its application to therapeutics is a field that attracted the
attention of the medical, pharmaceutical, and modeling communities during the early days of …
attention of the medical, pharmaceutical, and modeling communities during the early days of …