[HTML][HTML] Resistance mechanism of acute myeloid leukemia cells against daunorubicin and cytarabine: a literature review
Acute myeloid leukemia (AML) is a hematological malignancy commonly found in adult
patients. Low overall survival and resistance to therapy are the main issues in AML. The first …
patients. Low overall survival and resistance to therapy are the main issues in AML. The first …
Synthesis, anticancer activity and potential application of diosgenin modified cancer chemotherapeutic agent cytarabine
AM Liao, B Cai, JH Huang, M Hui, KK Lee… - Food and Chemical …, 2021 - Elsevier
Diosgenin (DG), a steroidal saponin, is mainly found in yam tubers. DG and its derivatives
displayed significant pharmacological activities against inflammatory, hyperlipidemia, and …
displayed significant pharmacological activities against inflammatory, hyperlipidemia, and …
Lower RNA expression of ALDH1A1 distinguishes the favorable risk group in acute myeloid leukemia
GM Dancik, IF Voutsas, S Vlahopoulos - Molecular Biology Reports, 2022 - Springer
The expression and activity of enzymes that belong to the aldehyde dehydrogenases is a
characteristic of both normal and malignant stem cells. ALDH1A1 is an enzyme critical in …
characteristic of both normal and malignant stem cells. ALDH1A1 is an enzyme critical in …
Ganoderma lucidum polysaccharide inhibits the proliferation of leukemic cells through apoptosis
M Zhong, J Huang, P Mao, C He, D Yuan… - Acta Biochimica …, 2022 - abp.ptbioch.edu.pl
Objective: To investigate the cytotoxic effect of polysaccharides derived from Ganoderma
lucidum on T lymphocyte leukemia cells. Methods: Water-soluble polysaccharides were …
lucidum on T lymphocyte leukemia cells. Methods: Water-soluble polysaccharides were …
Open-label phase II prospective, randomized, controlled study of romyelocel-L myeloid progenitor cells to reduce infection during induction chemotherapy for acute …
PM Desai, J Brown, S Gill, MM Solh… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Standard cytotoxic induction chemotherapy for acute myeloid leukemia (AML)
results in prolonged neutropenia and risk of infection. Romyelocel-L is a universal …
results in prolonged neutropenia and risk of infection. Romyelocel-L is a universal …
HDAC8 promotes daunorubicin resistance of human acute myeloid leukemia cells via regulation of IL-6 and IL-8
J Wu, L Zhang, Y Feng, B Khadka, Z Fang… - Biological …, 2021 - degruyter.com
The chemoresistance is one of the major challenges for acute myeloid leukemia (AML)
treatment. We found that the expression of histone deacetylase 8 (HDAC8) was increased in …
treatment. We found that the expression of histone deacetylase 8 (HDAC8) was increased in …
Long noncoding RNA SATB1-AS1 contributes to the chemotherapy resistance through the microRNA-580/2'-5'-oligoadenylate synthetase 2 axis in acute myeloid …
H Zhou, X Jia, F Yang, P Shi - Bioengineered, 2021 - Taylor & Francis
Acute myeloid leukemia (AML) represents a hematopoietic cancer with an invasive property.
Chemoresistance blunts the therapeutic effect of chemotherapeutics in AML. Long …
Chemoresistance blunts the therapeutic effect of chemotherapeutics in AML. Long …
[HTML][HTML] Ferroptosis in Health and Disease
Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various
degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and …
degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and …
[HTML][HTML] Treating hematological malignancies with drugs inhibiting ribosome biogenesis: when and why
E Derenzini, A Rossi, D Treré - Journal of Hematology & Oncology, 2018 - Springer
It is well known that chemotherapy can cure only some cancers in advanced stage, mostly
those with an intact p53 pathway. Hematological cancers such as lymphoma and certain …
those with an intact p53 pathway. Hematological cancers such as lymphoma and certain …
Inhibition of mitochondrial complex III or dihydroorotate dehydrogenase (DHODH) triggers formation of poly(A)+ RNA foci adjacent to nuclear speckles following …
S Miyake, S Masuda - RNA biology, 2022 - Taylor & Francis
Intracellular and intercellular signalling networks play an essential role in optimizing cellular
homoeostasis and are thought to be partly reflected in nuclear mRNA dynamics. However …
homoeostasis and are thought to be partly reflected in nuclear mRNA dynamics. However …