Exogenous and endogenous sources of chemical species can react, directly or after
metabolic activation, with DNA to yield DNA adducts. If not repaired, DNA adducts may …

Damage to DNA and RNA caused by oxidative mechanisms has been well-studied for its
potential role in the development of human disease. Only recently, though, have we begun …

Structural modifications of nucleobases within the deoxyribonucleic acid (DNA) of living cells
can be induced as a result of actions of specialized DNA-modifying enzymes (creating …

Exposure to endogenous and exogenous chemicals can lead to the formation of structurally
modified DNA bases (DNA adducts). If not repaired, these nucleobase lesions can cause …

The development of new strategies designed to detect DNA damage caused by oxidative
stress and other means may advance our understanding of the roles of such types of …

Furan is a toxic and carcinogenic compound used in industry and commonly found in the
environment. The mechanism of furan's carcinogenesis is not well-understood and may …

Acrolein, a widely distributed environmental pollutant, reacts with dGuo in DNA to form two
pairs of 1, N2-propano-dGuo adducts:(6 R/S)-3-(2 '-deoxyribos-1 '-yl)-5, 6, 7, 8-tetrahydro-6 …

The tobacco-specific nitrosamines N '-nitrosonornicotine (NNN, 1) and 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 2) are potent carcinogens in rodents …

Tobacco smoke is a complex mixture of more than 7000 chemicals, of which many are toxic
and/or carcinogenic. Many hazard assessments of tobacco have focused on individual …

Methods for determining the differential susceptibility of human organs to DNA damage have
not yet been explored to any large extent due to technical constraints. The development of …