Living species are continuously subjected to all extrinsic forms of reactive oxidants and
others that are produced endogenously. There is extensive literature on the generation and …

Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …

Mitochondria play a key role in both health and disease. Their function is not limited to
energy production but serves multiple mechanisms varying from iron and calcium …

Neurons and glia maintain central nervous system (CNS) homeostasis through diverse
mechanisms of intra-and intercellular signaling. Some of these interactions include the …

Senolytics are a category of drugs that reduce the impact of cellular senescence, an effect
associated with a range of chronic and age‐related diseases. Since the discovery of the first …

Human disease pathophysiology commonly involves metabolic disruption at both the
cellular and subcellular levels. Isolated mitochondria are a powerful model for separating …

Obesity is one of the prominent global health issues, contributing to the growing prevalence
of insulin resistance and type 2 diabetes. Chronic inflammation in adipose tissue is …

Cardiovascular disease (CVD) affects one in three adults and remains the leading cause of
death in America. Advancing age is a major risk factor for CVD. Recent plateaus in CVD …

Type 2 diabetes is a chronic metabolic disease that affects mitochondrial function. In this
context, the rescue mechanisms of mitochondrial health, such as mitophagy and …

The role of mitochondria in cardiovascular diseases is receiving ever growing attention. As a
central player in the regulation of cellular metabolism and a powerful controller of cellular …