[HTML][HTML] Secondary nucleation in amyloid formation
M Törnquist, TCT Michaels, K Sanagavarapu… - Chemical …, 2018 - pubs.rsc.org
Nucleation of new peptide and protein aggregates on the surfaces of amyloid fibrils of the
same peptide or protein has emerged in the past two decades as a major pathway for both …
same peptide or protein has emerged in the past two decades as a major pathway for both …
[HTML][HTML] Monomer-dependent secondary nucleation in amyloid formation
S Linse - Biophysical reviews, 2017 - Springer
Secondary nucleation of monomers on the surface of an already existing aggregate that is
formed from the same kind of monomers may lead to autocatalytic amplification of a self …
formed from the same kind of monomers may lead to autocatalytic amplification of a self …
Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide
Oligomeric species populated during the aggregation of the Aβ42 peptide have been
identified as potent cytotoxins linked to Alzheimer's disease, but the fundamental molecular …
identified as potent cytotoxins linked to Alzheimer's disease, but the fundamental molecular …
Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils
Amyloid-β (Aβ) is a 39–42 residue protein produced by the cleavage of the amyloid
precursor protein (APP), which subsequently aggregates to form cross-β amyloid fibrils that …
precursor protein (APP), which subsequently aggregates to form cross-β amyloid fibrils that …
Peptide dimer structure in an Aβ (1–42) fibril visualized with cryo-EM
Alzheimer's disease (AD) is a fatal neurodegenerative disorder in humans and the main
cause of dementia in aging societies. The disease is characterized by the aberrant formation …
cause of dementia in aging societies. The disease is characterized by the aberrant formation …
Monomeric Aβ1–40 and Aβ1–42 Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil
The pathogenesis of Alzheimer's disease is characterized by the aggregation and fibrillation
of amyloid peptides Aβ1–40 and Aβ1–42 into amyloid plaques. Despite strong potential …
of amyloid peptides Aβ1–40 and Aβ1–42 into amyloid plaques. Despite strong potential …
Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide
SIA Cohen, R Cukalevski, TCT Michaels, A Šarić… - Nature …, 2018 - nature.com
Mapping free-energy landscapes has proved to be a powerful tool for studying reaction
mechanisms. Many complex biomolecular assembly processes, however, have remained …
mechanisms. Many complex biomolecular assembly processes, however, have remained …
Amyloid β 42 fibril structure based on small-angle scattering
Amyloid fibrils are associated with a number of neurodegenerative diseases, including fibrils
of amyloid β42 peptide (Aβ42) in Alzheimer's disease. These fibrils are a source of toxicity to …
of amyloid β42 peptide (Aβ42) in Alzheimer's disease. These fibrils are a source of toxicity to …
Mechanism of secondary nucleation at the single fibril level from direct observations of Aβ42 aggregation
The formation of amyloid fibrils and oligomers is a hallmark of several neurodegenerative
disorders, including Alzheimer's disease (AD), and contributes to the disease pathway. To …
disorders, including Alzheimer's disease (AD), and contributes to the disease pathway. To …
The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils
D Thacker, K Sanagavarapu, B Frohm… - Proceedings of the …, 2020 - National Acad Sciences
Crystals, nanoparticles, and fibrils catalyze the generation of new aggregates on their
surface from the same type of monomeric building blocks as the parent assemblies. This …
surface from the same type of monomeric building blocks as the parent assemblies. This …