Pathophysiology and therapeutic approaches to acute decompensated heart failure

JN Njoroge, JR Teerlink - Circulation research, 2021 - Am Heart Assoc
Acute decompensated heart failure (ADHF) is one of the leading admission diagnoses
worldwide, yet it is an entity with incompletely understood pathophysiology and limited …

[HTML][HTML] Molecular mechanisms for ketone body metabolism, signaling functions, and therapeutic potential in cancer

CY Hwang, W Choe, KS Yoon, J Ha, SS Kim, EJ Yeo… - Nutrients, 2022 - mdpi.com
The ketone bodies (KBs) β-hydroxybutyrate and acetoacetate are important alternative
energy sources for glucose during nutrient deprivation. KBs synthesized by hepatic …

Mechanistic insights of empagliflozin in nondiabetic patients with HFrEF: from the EMPA-TROPISM study

JA Requena-Ibáñez, CG Santos-Gallego… - Heart Failure, 2021 - jacc.org
Objectives The goal of this study was to evaluate the effect of empagliflozin, in addition to
optimal medical treatment, on epicardial adipose tissue (EAT), interstitial myocardial fibrosis …

Cardio-onco-metabolism: metabolic remodelling in cardiovascular disease and cancer

A Karlstaedt, J Moslehi, RA de Boer - Nature Reviews Cardiology, 2022 - nature.com
Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in
the world. The emerging field of cardio-oncology has revealed that these seemingly …

Metabolomic profiling of the effects of dapagliflozin in heart failure with reduced ejection fraction: DEFINE-HF

S Selvaraj, Z Fu, P Jones, LC Kwee, SL Windsor… - Circulation, 2022 - Am Heart Assoc
Background: Sodium-glucose cotransporter-2 inhibitors are foundational therapy in patients
with heart failure with reduced ejection fraction (HFrEF), but underlying mechanisms of …

[HTML][HTML] The ketogenic diet and cardiovascular diseases

D Dyńka, K Kowalcze, A Charuta, A Paziewska - Nutrients, 2023 - mdpi.com
The most common and increasing causes of death worldwide are cardiovascular diseases
(CVD). Taking into account the fact that diet is a key factor, it is worth exploring this aspect of …

Masticatory system–inspired microneedle theranostic platform for intelligent and precise diabetic management

J Yang, S Zheng, D Ma, T Zhang, X Huang… - Science …, 2022 - science.org
Integrated systems for diabetic theranostics present advanced technology to regulate
diabetes yet still have critical challenges in terms of accuracy, long-term monitoring, and …

Cardioprotective effect of empagliflozin and circulating ketone bodies during acute myocardial infarction

CG Santos-Gallego, JA Requena-Ibáñez… - Circulation …, 2023 - Am Heart Assoc
Background: SGLT2i (sodium-glucose cotransporter-2 inhibitors) improve clinical outcomes
in patients with heart failure, but the mechanisms of action are not completely understood …

Cardiac metabolism in HFpEF: from fuel to signalling

F Capone, C Sotomayor-Flores, D Bode… - Cardiovascular …, 2022 - academic.oup.com
Heart failure (HF) is marked by distinctive changes in myocardial uptake and utilization of
energy substrates. Among the different types of HF, HF with preserved ejection fraction …

[HTML][HTML] The effect of ketogenic diet on shared risk factors of cardiovascular disease and cancer

N Mohammadifard, F Haghighatdoost, M Rahimlou… - Nutrients, 2022 - mdpi.com
Cardiovascular disease (CVD) and cancer are the first and second leading causes of death
worldwide, respectively. Epidemiological evidence has demonstrated that the incidence of …