Functional extracellular vesicles for regenerative medicine

HY Kim, S Kwon, W Um, S Shin, CH Kim, JH Park… - Small, 2022 - Wiley Online Library
The unique biological characteristics and promising clinical potential of extracellular
vesicles (EVs) have galvanized EV applications for regenerative medicine. Recognized as …

Identification of storage conditions stabilizing extracellular vesicles preparations

A Görgens, G Corso, DW Hagey… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) play a key role in many physiological and pathophysiological
processes and hold great potential for therapeutic and diagnostic use. Despite significant …

The evolving regulatory landscape in regenerative medicine

DJ Beetler, DN Di Florio, EW Law, CM Groen… - Molecular aspects of …, 2023 - Elsevier
Regenerative medicine as a field has emerged as a new component of modern medicine
and medical research that encompasses a wide range of products including cellular and …

Enhancing extracellular vesicle analysis by integration of large-volume sample stacking in capillary electrophoresis with asymmetrical flow field-flow fractionation

Z Gao, Z Li, Z Hutchins, Q Zhang, W Zhong - Analytical Chemistry, 2023 - ACS Publications
Extracellular vesicles (EVs) play important roles in cell–cell communication and pathological
development. Cargo profiling for the EVs present in clinical specimens can provide valuable …

[HTML][HTML] Comprehensive proteomic profiling of plasma and serum phosphatidylserine-positive extracellular vesicles reveals tissue-specific proteins

S Muraoka, M Hirano, J Isoyama, S Nagayama… - IScience, 2022 - cell.com
Extracellular vesicles (EVs) are ubiquitously secreted by almost all tissues and carry many
cargoes, including proteins, RNAs, and lipids, which are related to various biological …

Comparison of extracellular vesicle isolation processes for therapeutic applications

S Williams, M Fernandez-Rhodes… - Journal of Tissue …, 2023 - journals.sagepub.com
While extracellular vesicles (EVs) continue to gain interest for therapeutic applications, their
clinical translation is limited by a lack of optimal isolation methods. We sought to determine …

From conventional to microfluidic: progress in extracellular vesicle separation and individual characterization

M Chen, S Lin, C Zhou, D Cui, H Haick… - Advanced Healthcare …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are nanoscale membrane vesicles, which contain a wide variety
of cargo such as proteins, miRNAs, and lipids. A growing body of evidence suggests that …

[HTML][HTML] Size-exclusion chromatography combined with ultrafiltration efficiently isolates extracellular vesicles from human blood samples in health and disease

C Franco, A Ghirardello, L Bertazza… - International Journal of …, 2023 - mdpi.com
There is still a need for an efficient method for the isolation of extracellular vesicles (EVs)
from human blood that provides a reliable yield with acceptable purity. Blood is a source of …

[HTML][HTML] Extracellular vesicles-ceRNAs as ovarian cancer biomarkers: looking into circRNA-miRNA-mRNA code

G Cammarata, N Barraco, I Giusti, V Gristina, V Dolo… - Cancers, 2022 - mdpi.com
Simple Summary Patients with ovarian cancer have a very poor chance of long-term
survival, usually due to advanced disease at the time of diagnosis. Emerging evidence …

[HTML][HTML] Liquid biopsies to occult brain metastasis

AU Rehman, P Khan, SK Maurya, JA Siddiqui… - Molecular cancer, 2022 - Springer
Brain metastasis (BrM) is a major problem associated with cancer-related mortality, and
currently, no specific biomarkers are available in clinical settings for early detection. Liquid …