The microbial etiology of community-acquired pneumonia in adults: from classical bacteriology to host transcriptional signatures

NJ Gadsby, DM Musher - Clinical microbiology reviews, 2022 - Am Soc Microbiol
All modern advances notwithstanding, pneumonia remains a common infection with
substantial morbidity and mortality. Understanding of the etiology of pneumonia continues to …

Respiratory tract infections and laboratory diagnostic methods: a review with a focus on syndromic panel-based assays

A Calderaro, M Buttrini, B Farina, S Montecchini… - Microorganisms, 2022 - mdpi.com
Respiratory tract infections (RTIs) are the focus of developments in public health, given their
widespread distribution and the high morbidity and mortality rates reported worldwide. The …

A sample-to-answer, quantitative real-time PCR system with low-cost, gravity-driven microfluidic cartridge for rapid detection of SARS-CoV-2, influenza A/B, and …

Y Zai, C Min, Z Wang, Y Ding, H Zhao, E Su, N He - Lab on a Chip, 2022 - pubs.rsc.org
The pandemic of coronavirus disease 2019 (COVID-19), due to the novel coronavirus
(SARS-CoV-2), has created an unprecedented threat to the global health system, especially …

Co-infections in COVID-19 critically ill and antibiotic management: a prospective cohort analysis

A Verroken, A Scohy, L Gérard, X Wittebole… - Critical Care, 2020 - Springer
International guidelines recommend the initiation of empirical antibiotherapy for possible
associated bacterial pneumonia in COVID-19 critically ill yet further suggesting a rapid …

The threat of multidrug-resistant/extensively drug-resistant Gram-negative respiratory infections: another pandemic

D Reynolds, JP Burnham, CV Guillamet… - European …, 2022 - Eur Respiratory Soc
Antibiotic resistance is recognised as a global threat to human health by national healthcare
agencies, governments and medical societies, as well as the World Health Organization …

Evaluation of point-of-care multiplex polymerase chain reaction in guiding antibiotic treatment of patients acutely admitted with suspected community-acquired …

MB Cartuliares, FS Rosenvinge, CB Mogensen… - PLoS …, 2023 - journals.plos.org
Background Rapid and accurate detection of pathogens is needed in community-acquired
pneumonia (CAP) to enable appropriate antibiotics and to slow the development of antibiotic …

Impact of rapid multiplex PCR on management of antibiotic therapy in COVID-19-positive patients hospitalized in intensive care unit

N Maataoui, L Chemali, J Patrier, A Tran Dinh… - European Journal of …, 2021 - Springer
Because the diagnosis of co/superinfection in COVID-19 patients is challenging, empirical
antibiotic therapy is frequently initiated until microbiological analysis results. We evaluated …

Rapid syndromic PCR testing in patients with respiratory tract infections reduces time to results and improves microbial yield

S Serigstad, D Markussen, HMS Grewal, M Ebbesen… - Scientific Reports, 2022 - nature.com
Lack of rapid and comprehensive microbiological diagnosis in patients with community
acquired pneumonia (CAP) hampers appropriate antimicrobial therapy. This study evaluates …

Performance evaluation of a PCR panel (FilmArray® Pneumonia Plus) for detection of respiratory bacterial pathogens in respiratory specimens: A systematic review …

AC Moy, A Kimmoun, T Merkling, B Berçot… - … Critical Care & Pain …, 2023 - Elsevier
Background Accuracy and timing of antibiotic therapy remain a challenge for lower
respiratory tract infections. New molecular techniques using Multiplex Polymerase Chain …

Multicentre evaluation of two multiplex PCR platforms for the rapid microbiological investigation of nosocomial pneumonia in UK ICUs: the INHALE WP1 study

VI Enne, A Aydin, R Baldan, DR Owen, H Richardson… - Thorax, 2022 - thorax.bmj.com
Background Culture-based microbiological investigation of hospital-acquired or ventilator-
associated pneumonia (HAP or VAP) is insensitive, with aetiological agents often …