The view of CD4 T‐cell‐mediated immunity as a balance between distinct lineages of Th1
and Th2 cells has changed dramatically. Identification of the IL‐17 family of cytokines and of …

The prognosis in systemic lupus erythematosus (SLE) has improved due to better treatment
and care, but cardiovascular disease (CVD) still remains an important clinical problem, since …

Inflammatory arthritis occurs in many diseases and is characterized by joint inflammation
and damage. However, the inflammatory state in arthritis is commonly associated with …

Cellular senescence is a key mechanism of age-related vascular endothelial dysfunction.
Interleukin-17A (IL-17A) is an inflammatory cytokine produced by Th17 cells (a subgroup of …

The IL-17 cytokine family comprising IL-17A to IL-17F and receptor subunits IL-17RA to IL-
17RE represents a genetically ancient intercellular network regulating local tissue …

Background Activated T cells and dendritic cells (DC s) occur in atherosclerotic plaques.
Proprotein convertase subtilisin kexin 9 (PCSK 9) targets the LDL‐receptor (LDLR) and …

Psoriasis and psoriatic arthritis are chronic immune-mediated disorders with involvement of
interleukin (IL)-17 cytokines in their pathogenesis. IL-17A has been considered to be the …

Background Adaptive immunity has been implicated in atherosclerosis in animal models
and small clinical studies. Whether chronic immune activation is associated with …

Background Activated T cells and dendritic cells (DC s) are colocalized in atherosclerotic
plaques in association with plaque rupture. Oxidized low‐density lipoprotein (ox LDL) …

Psoriasis is a chronic, systemic, immune-mediated inflammatory disorder that is associated
with a significantly increased risk of cardiovascular disease (CVD). Studies have shown that …