Metabolomics for investigating physiological and pathophysiological processes

DS Wishart - Physiological reviews, 2019 - journals.physiology.org
Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person

L Koklesova, A Mazurakova, M Samec, K Biringer… - EPMA Journal, 2021 - Springer
Homocysteine (Hcy) metabolism is crucial for regulating methionine availability, protein
homeostasis, and DNA-methylation presenting, therefore, key pathways in post-genomic …

The controversial role of homocysteine in neurology: from labs to clinical practice

R Moretti, P Caruso - International journal of molecular sciences, 2019 - mdpi.com
Homocysteine (Hcy) is a sulfur-containing amino acid that is generated during methionine
metabolism. Physiologic Hcy levels are determined primarily by dietary intake and vitamin …

Diagnostic, prognostic, and mechanistic biomarkers of diabetes mellitus-associated cognitive decline

H Ehtewish, A Arredouani, O El-Agnaf - International journal of molecular …, 2022 - mdpi.com
Cognitive dysfunctions such as mild cognitive impairment (MCI), Alzheimer's disease (AD),
and other forms of dementia are recognized as common comorbidities of type 2 diabetes …

Neuroprotective strategies for neurological disorders by natural products: an update

MU Rehman, AF Wali, A Ahmad… - Current …, 2019 - ingentaconnect.com
Nature has bestowed mankind with surplus resources (natural products) on land and water.
Natural products have a significant role in the prevention of disease and boosting of health …

Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease

KG Goozee, TM Shah, HR Sohrabi… - British Journal of …, 2016 - cambridge.org
Curcumin derived from turmeric is well documented for its anti-carcinogenic, antioxidant and
anti-inflammatory properties. Recent studies show that curcumin also possesses …

Epilepsy is a neurological and a systemic disorder

AWC Yuen, MR Keezer, JW Sander - Epilepsy & Behavior, 2018 - Elsevier
The basic pathophysiology of epilepsy is still not fully understood. Epidemiological evidence
for epilepsy seems to suggest that it may not only be the propensity for seizures to occur …

Reductive metabolites of curcumin and their therapeutic effects

A Pandey, M Chaturvedi, S Mishra, P Kumar… - Heliyon, 2020 - cell.com
Curcumin, a secondary metabolite from the turmeric plant is one of the most promising
natural products, which has been studied extensively for decades. It has demonstrated …

[HTML][HTML] p38 MAPK and PI3K/AKT signalling cascades inParkinson's disease

SK Jha, NK Jha, R Kar, RK Ambasta… - International journal of …, 2015 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is a chronic neurodegenerative condition which has the second
largest incidence rate among all other neurodegenerative disorders barring Alzheimer's …

Targeting T-type/CaV3. 2 channels for chronic pain

S Cai, K Gomez, A Moutal, R Khanna - Translational Research, 2021 - Elsevier
T-type calcium channels regulate neuronal excitability and are important contributors of pain
processing. CaV3. 2 channels are the major isoform expressed in nonpeptidergic and …