Bromelain a potential bioactive compound: a comprehensive overview from a pharmacological perspective

AJ Chakraborty, S Mitra, TE Tallei, AM Tareq, F Nainu… - Life, 2021 - mdpi.com
Bromelain is an effective chemoresponsive proteolytic enzyme derived from pineapple
stems. It contains several thiol endopeptidases and is extracted and purified via several …

Potential role of bromelain in clinical and therapeutic applications

V Rathnavelu, NB Alitheen, S Sohila… - Biomedical …, 2016 - spandidos-publications.com
Pineapple has been used as part of traditional folk medicine since ancient times and it
continues to be present in various herbal preparations. Bromelain is a complex mixture of …

Properties and therapeutic application of bromelain: a review

R Pavan, S Jain, Shraddha… - Biotechnology research …, 2012 - Wiley Online Library
Bromelain belongs to a group of protein digesting enzymes obtained commercially from the
fruit or stem of pineapple. Fruit bromelain and stem bromelainare prepared differently and …

Bromelain, a Group of Pineapple Proteolytic Complex Enzymes (Ananas comosus) and Their Possible Therapeutic and Clinical Effects. A Summary

C Varilla, M Marcone, L Paiva, J Baptista - Foods, 2021 - mdpi.com
Bromelain is a complex combination of multiple endopeptidases of thiol and other
compounds derived from the pineapple fruit, stem and/or root. Fruit bromelain and stem …

Plant-derived natural products in cancer research: extraction, mechanism of action, and drug formulation

WH Talib, I Alsalahat, S Daoud, RF Abutayeh… - Molecules, 2020 - mdpi.com
Cancer is one of the main causes of death globally and considered as a major challenge for
the public health system. The high toxicity and the lack of selectivity of conventional …

Bromelain's activity and potential as an anti-cancer agent: current evidence and perspectives

K Chobotova, AB Vernallis, FAA Majid - Cancer letters, 2010 - Elsevier
The medicinal qualities of pineapple are recognized in many traditions in South America,
China and Southeast Asia. These qualities are attributed to bromelain, a 95%-mixture of …

[HTML][HTML] Native foods from Brazilian biodiversity as a source of bioactive compounds

VB Oliveira, LT Yamada, CW Fagg… - Food Research …, 2012 - Elsevier
The interest in South American native plant species has been growing in recent years due to
their health benefits. Brazil is one of the world's mega-diverse locations with over 40,000 …

Bromelain: Methods of extraction, purification and therapeutic applications

Z Manzoor, A Nawaz, H Mukhtar, I Haq - Brazilian Archives of Biology …, 2016 - SciELO Brasil
Bromelain is a concoction of sulfhydryl proteolytic enzymes. Depending upon the site of
extraction it can be regarded as either stem bromelain (SBM)(EC 3.4. 22.32) or fruit …

Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway

K Bhui, S Prasad, J George, Y Shukla - Cancer letters, 2009 - Elsevier
Chemoprevention impels the pursuit for either single targeted or cocktail of multi-targeted
agents. Bromelain, potential agent in this regard, is a pharmacologically active compound …

Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy

TC Chang, PL Wei, PT Makondi, WT Chen, CY Huang… - PloS one, 2019 - journals.plos.org
Advanced colorectal cancer (CRC) survival rates are still low despite advances in cytotoxic
and targeted therapies. The development of new effective or alternative therapies is …