Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …

Since the discovery that non-small cell lung cancer (NSCLC) is driven by epidermal growth
factor receptor (EGFR) mutations, the EGFR tyrosine kinase inhibitors (EGFR-TKIs, eg …

Overwhelming epidemiological evidence demonstrate that cardiovascular disease and
cancer represent major health burdens in the United States, and they are the leading causes …

Phylloquinone (vitamin K1) and menaquinones (vitamin K2 family) are essential for post-
translational γ-carboxylation of a small number of proteins, including clotting factors. These …

Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein,
which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a …

Background Transmembrane serine protease 4 (TMPRSS4) is a cell surface–anchored
serine protease. Elevated expression of TMPRSS4 correlates with poor prognosis in …

Recent advances in tiling array and high throughput analyses revealed that at least 87.3% of
the human genome is actively transcribed, though< 3% of the human genome encodes …

Loss of the tumor suppressor phosphatase and tensin homologue deleted on chromosome
10 (PTEN), which negatively regulates the PI3K–AKT–mTOR pathway, is strongly linked to …

Lung cancer‐associated mortality is the most common cause of cancer death worldwide.
Non‐coding RNA s (nc RNA s), with no protein‐coding ability, have multiple biological roles …

We describe a multipurpose technology platform, termed μSCALE (microcapillary single-cell
analysis and laser extraction), that enables massively parallel, quantitative biochemical and …