Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Apoptosis, also named programmed cell death, is a fundament process required for
morphogenetic homeostasis during early development and in pathophysiological …

Impaired apoptosis plays a central role in cancer development and limits the efficacy of
conventional cytotoxic therapies. Deepening understanding of how opposing factions of the …

Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members
play important roles in controlling apoptotic cell death. Abnormal over-expression of pro …

The ability of a cell to undergo mitochondrial apoptosis is governed by pro-and anti-
apoptotic members of the BCL-2 protein family. The equilibrium of pro-versus anti-apoptotic …

Defects in apoptotic cell death can promote cancer and impair responses of malignant cells
to anti-cancer therapy. Pro-survival BCL-2 proteins prevent apoptosis by keeping the cell …

The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell
suicide programme that is essential for development, tissue homeostasis and immunity. Too …

Almost 30 years ago it was first appreciated that anti-apoptotic B-cell lymphoma-2 (BCL-2)
prevents the induction of apoptosis not only in malignant cells, but also in normal cellular …

Chemotherapy is one of the standard methods of treatment in many cancers. While
chemotherapy is often capable of inducing cell death in tumors and reducing the tumor bulk …

Hundreds of billions of platelets are cleared daily from circulation via efficient and highly
regulated mechanisms. These mechanisms may be stimulated by exogenous reagents or …