Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study
H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …
activated by various stimuli, transducing a quick but transient transcriptional activity, to …
NF‐κB signaling in inflammation and cancer
T Zhang, C Ma, Z Zhang, H Zhang, H Hu - MedComm, 2021 - Wiley Online Library
Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …
in 1986, extraordinary efforts have been made to understand the function and regulating …
Regulation of TNF-induced osteoclast differentiation
Z Yao, SJ Getting, IC Locke - Cells, 2021 - mdpi.com
Increased osteoclast (OC) differentiation and activity is the critical event that results in bone
loss and joint destruction in common pathological bone conditions, such as osteoporosis …
loss and joint destruction in common pathological bone conditions, such as osteoporosis …
[HTML][HTML] The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases
The nuclear factor kappa B (NF-êB) family of transcription factors plays an essential role as
stressors in the cellular environment, and controls the expression of important regulatory …
stressors in the cellular environment, and controls the expression of important regulatory …
Ubiquitination in the regulation of inflammatory cell death and cancer
The ubiquitin system is complex, multifaceted, and is crucial for the modulation of a vast
number of cellular processes. Ubiquitination is tightly regulated at different levels by a range …
number of cellular processes. Ubiquitination is tightly regulated at different levels by a range …
NF-κB, inflammation, immunity and cancer: coming of age
K Taniguchi, M Karin - Nature Reviews Immunology, 2018 - nature.com
Fourteen years have passed since nuclear factor-κB (NF-κB) was first shown to serve as a
molecular lynchpin that links persistent infections and chronic inflammation to increased …
molecular lynchpin that links persistent infections and chronic inflammation to increased …
The non-canonical NF-κB pathway in immunity and inflammation
SC Sun - Nature reviews immunology, 2017 - nature.com
The nuclear factor-κB (NF-κB) family of transcription factors is activated by canonical and
non-canonical signalling pathways, which differ in both signalling components and …
non-canonical signalling pathways, which differ in both signalling components and …
Signaling via the NFκB system
The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune
development, immune responses, inflammation, and cancer. The NFκB signaling system …
development, immune responses, inflammation, and cancer. The NFκB signaling system …
The regulation of NF-κB subunits by phosphorylation
F Christian, EL Smith, RJ Carmody - Cells, 2016 - mdpi.com
The NF-κB transcription factor is the master regulator of the inflammatory response and is
essential for the homeostasis of the immune system. NF-κB regulates the transcription of …
essential for the homeostasis of the immune system. NF-κB regulates the transcription of …
Tumor necrosis factor receptor-associated factor regulation of nuclear factor κB and mitogen-activated protein kinase pathways
Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of structurally
related proteins that transduces signals from members of TNFR superfamily and various …
related proteins that transduces signals from members of TNFR superfamily and various …