The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a
critical role in cancer. Although research often concentrates on the tumor's cellular aspect …

Infections, cardiovascular disease, and cancer are major causes of disease and death
worldwide. Neutrophils are inescapably associated with each of these health concerns, by …

Mesenchymal stem cells (MSCs) are multipotent stromal cells that have the ability to
differentiate into multiple cell types. Several studies have shown that exosomes secreted by …

Colorectal cancer (CRC) develops by genetic and epigenetic alterations. However, the
molecular mechanisms underlying metastatic dissemination remain unclear and could …

Simple Summary Extracellular matrix is a three-dimensional network of macromolecules that
provide structural and biochemical support to surrounding cells. Extracellular matrix plays a …

There remains a vital necessity for new therapeutic approaches to combat metastatic
cancers, which cause globally over 8 million deaths per year. Mesenchymal stem cells …

Cancer initiation and progression heavily rely on microenvironmental cues derived from
various components of the niche including the extracellular matrix (ECM). ECM is a complex …

Abstract Background Cancer-associated fibroblasts (CAFs) play multiple roles in regulating
tumor metastasis and treatment response. Current clinical indicators are insufficient to …