PCSK9 degrades low-density lipoprotein cholesterol (LDL) receptors and subsequently
increases serum LDL cholesterol. Clinical trials show that inhibition of PCSK9 efficiently …

The endothelium, which forms the inner cellular lining of blood vessels and lymphatics, is a
highly metabolically active organ that is involved in many physiopathological processes …

An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor
for genesis of atherosclerosis. Ox-LDL plays a more important role in the genesis and …

Abstract LOX-1, a lectin-like 52-kD receptor for oxidized low-density lipoproteins (ox-LDL), is
present primarily on endothelial cells. This receptor is upregulated by ox-LDL itself and by …

Atherosclerosis is associated with oxidative stress and inflammation, and upregulation of
LOX-1, an endothelial receptor for oxidized LDL (oxLDL). Here, we describe generation of …

and modulation of matrix metalloproteinase (MMP) activity, toward conditions favoring
compromise of the fibrous cap. 27–29 On plaque rupture, activated platelets may interact …

The function of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9), a novel plasma
protein, has mainly been involved in cholesterol metabolism in the liver, while, more …

The identification of which cell types undergo apoptosis within the atherosclerotic lesion, the
extracellular factors that impinge on these cells, and the intracellular mechanisms that …

Cardiovascular disease (CVD) is one of the leading major causes of morbidity and mortality
worldwide. It may result from the interactions between multiple genetic and environmental …

LOX-1 is an endothelial receptor for oxidized low-density lipoprotein (oxLDL), a key
molecule in the pathogenesis of atherosclerosis. The basal expression of LOX-1 is low but …