Ten years of EWAS

S Wei, J Tao, J Xu, X Chen, Z Wang, N Zhang… - Advanced …, 2021 - Wiley Online Library
Epigenome‐wide association study (EWAS) has been applied to analyze DNA methylation
variation in complex diseases for a decade, and epigenome as a research target has …

[HTML][HTML] Computational challenges in detection of cancer using cell-free DNA methylation

M Sharma, RK Verma, S Kumar, V Kumar - Computational and Structural …, 2022 - Elsevier
Cell-free DNA (cfDNA) methylation profiling is considered promising and potentially reliable
for liquid biopsy to study progress of diseases and develop reliable and consistent …

DNA methylation changes in the sperm of captive-reared fish: a route to epigenetic introgression in wild populations

D Rodriguez Barreto, C Garcia de Leaniz… - Molecular Biology …, 2019 - academic.oup.com
Interbreeding between hatchery-reared and wild fish, through deliberate stocking or
escapes from fish farms, can result in rapid phenotypic and gene expression changes in …

A three‐gene DNA methylation biomarker accurately classifies early stage prostate cancer

PG Patel, T Wessel, A Kawashima, JBA Okello… - The …, 2019 - Wiley Online Library
Background We identify and validate accurate diagnostic biomarkers for prostate cancer
through a systematic evaluation of DNA methylation alterations. Materials and methods We …

Integrative mapping of the dog epigenome: Reference annotation for comparative intertissue and cross-species studies

KH Son, MBD Aldonza, AR Nam, KH Lee, JW Lee… - Science …, 2023 - science.org
Dogs have become a valuable model in exploring multifaceted diseases and biology
relevant to human health. Despite large-scale dog genome projects producing high-quality …

Interplay between maternal Slc6a4 mutation and prenatal stress: a possible mechanism for autistic behavior development

CP Sjaarda, P Hecht, AJM McNaughton, A Zhou… - Scientific Reports, 2017 - nature.com
The low activity allele of the maternal polymorphism, 5HTTLPR, in the serotonin transporter,
SLC6A4, coupled with prenatal stress is reported to increase the risk for children to develop …

Goldmine integrates information placing genomic ranges into meaningful biological contexts

JM Bhasin, AH Ting - Nucleic acids research, 2016 - academic.oup.com
Bioinformatic analysis often produces large sets of genomic ranges that can be difficult to
interpret in the absence of genomic context. Goldmine annotates genomic ranges from any …

Epigenetic targeting of adipocytes inhibits high-grade serous ovarian cancer cell migration and invasion

J Tang, N Pulliam, A Özeş, A Buechlein, N Ding… - Molecular Cancer …, 2018 - AACR
Ovarian cancer (OC) cells frequently metastasize to the omentum, and adipocytes play a
significant role in ovarian tumor progression. Therapeutic interventions targeting aberrant …

[HTML][HTML] Data showing atherosclerosis-associated differentially methylated regions are often at enhancers

M Lacey, C Baribault, KC Ehrlich, M Ehrlich - Data in brief, 2019 - Elsevier
Atherosclerosis involves phenotypic modulation and transdifferentiation of vascular smooth
muscle cells (SMCs). Data are given in tabular or figure format that illustrate genome-wide …

Whole-genome differentially hydroxymethylated DNA regions among twins discordant for cardiovascular death

J Dai, M Leung, W Guan, HT Guo, RE Krasnow… - Genes, 2021 - mdpi.com
Epigenetics is a mechanism underlying cardiovascular disease. It is unknown whether DNA
hydroxymethylation is prospectively associated with the risk for cardiovascular death …