T is converted to a more potent androgen, DHT by the action of microsomal membrane
enzyme 5α reductase 2. Defects in 5α reductase 2 isozyme results in incomplete virilisation …

The term androgen refers to any natural or synthetic compounds that stimulate or control
development and maintenance of masculine characteristics. Most commonly, androgens …

The next generation antiandrogen, Apalutamide (Apa), improves both overall survival and
metastasis-free survival in men with castration-resistant prostate cancer (CRPC). In vitro and …

Three unrelated Spanish patients born with ambiguous genitalia, 46, XY karyotype, normal
testosterone (T) secretion, and extremely low 5a-reductase activity in genital skin fibroblasts …

Loss-of-function mutations in the steroid 5α-reductase 2 gene (SRD5A2) cause a disorder of
male sexual differentiation in which the prostate does not form and external genitalia …

Publisher Summary This chapter discusses the genetic abnormalities associated with
androgen resistance. Androgen resistance is described as a congenital genetic disorder that …

ABSTRACT Background: Congenital Adrenal Hyperplasia (CAH) is a group of autosomal
recessive disorders caused by deficiency of any of the steroidogenic enzymes involved in …

Mutations of the steroid 5α-reductase type 2 (SRD5A2) gene in 46, XY subjects cause
masculinization defects of varying degrees, due to reduced or impaired enzymatic activity. In …