Human stem cells for cardiac disease modeling and preclinical and clinical applications—are we on the road to success?

CD Correia, A Ferreira, MT Fernandes, BM Silva… - Cells, 2023 - mdpi.com
Cardiovascular diseases (CVDs) are pointed out by the World Health Organization (WHO)
as the leading cause of death, contributing to a significant and growing global health and …

Molecular and Cellular Effects of Hydrogen Peroxide on Human Lung Cancer Cells: Potential Therapeutic Implications

G Vilema-Enríquez, A Arroyo, M Grijalva… - Oxidative Medicine …, 2016 - Wiley Online Library
Lung cancer has a very high mortality‐to‐incidence ratio, representing one of the main
causes of cancer mortality worldwide. Therefore, new treatment strategies are urgently …

Use of stem cells as alternative methods to animal experimentation in predictive toxicology

TW Kim, JH Che, JW Yun - Regulatory toxicology and pharmacology, 2019 - Elsevier
Despite a major role of experimental animals in development of biomedical research, there
has been historical controversy surrounding animal research. Along with a strategy of 3Rs …

Quality control optimization for minimizing security risks associated with mesenchymal stromal cell-based product development

CLK Rebelatto, LM Boldrini-Leite, DR Daga… - International Journal of …, 2023 - mdpi.com
Mesenchymal stromal cells (MSCs) have been considered a therapeutic strategy in
regenerative medicine because of their regenerative and immunomodulatory properties …

In Vitro and in Vivo Analysis of Adhesive, Anti-Inflammatory, and Proangiogenic Properties of Novel 3D Printed Hyaluronic Acid Glycidyl Methacrylate Hydrogel …

T Später, AO Mariyanats, MA Syachina… - ACS Biomaterials …, 2020 - ACS Publications
In this study, we prepared hydrogel scaffolds for tissue engineering by computer-assisted
extrusion three-dimensional (3D) printing with photocured (λ= 445 nm) hyaluronic acid …

Environmental Chemicals Modulate Polar Bear (Ursus maritimus) Peroxisome Proliferator-Activated Receptor Gamma (PPARG) and Adipogenesis in Vitro

H Routti, R Lille-Langøy, MK Berg, T Fink… - … science & technology, 2016 - ACS Publications
We studied interactions between polar bear peroxisome proliferator-activated receptor
gamma (pbPPARG) and selected compounds using a luciferase reporter assay and …

Bifunctional electrochemical biosensor based on PB-MXene films for the real-time analysis and detection of living cancer cells

X Su, Q You, L Zhuang, Z Chang, M Ge, L Yang… - … of Pharmaceutical and …, 2023 - Elsevier
Circulating tumor cells (CTCs) are important prognostic markers for cancer diagnosis and
metastasis, and their detection is an important means to detect cancer metastasis. Herein …

[HTML][HTML] Genetic and epigenetic stability of stem cells: Epigenetic modifiers modulate the fate of mesenchymal stem cells

S Sharma, R Bhonde - Genomics, 2020 - Elsevier
Stem cell research has progressed widely and has been receiving a considerable attention
for its advantages and drawbacks. Despite their extensive therapeutic potential in …

Antibacterial and cytotoxic properties of star-shaped quaternary ammonium-functionalized polymers with different pendant groups

SY Nam, J Lee, SS Shin, HJ Yoo, M Yun, S Kim… - Polymer …, 2022 - pubs.rsc.org
The correlation between the structure and biological activity of polymers is critically
important for rationally designing effective antibacterial polymers. Here, the antibacterial …

Genotoxicity, oxidative stress and transcriptomic effects of Nitenpyram on human bone marrow mesenchymal stem cells

W Liu, Z Li, X Cui, F Luo, C Zhou, J Zhang… - Toxicology and Applied …, 2022 - Elsevier
Despite of the global contamination and ubiquitous exposure to nitenpyram (NIT), little
knowledge is available on the adverse effects to human health, with some evidence …