Synucleins: new data on misfolding, aggregation and role in diseases
A Surguchov, A Surguchev - Biomedicines, 2022 - mdpi.com
The synucleins are a family of natively unfolded (or intrinsically unstructured) proteins
consisting of α-, β-, and γ-synuclein involved in neurodegenerative diseases and cancer …
consisting of α-, β-, and γ-synuclein involved in neurodegenerative diseases and cancer …
[HTML][HTML] Liquid-liquid phase separation of protein tau: An emerging process in Alzheimer's disease pathogenesis
H Ainani, N Bouchmaa, RB Mrid, R El Fatimy - Neurobiology of disease, 2023 - Elsevier
Metabolic reactions within cells occur in various isolated compartments with or without
borders, the latter being known as membrane-less organelles (MLOs). The MLOs show …
borders, the latter being known as membrane-less organelles (MLOs). The MLOs show …
Heterotypic electrostatic interactions control complex phase separation of tau and prion into multiphasic condensates and co-aggregates
SK Rai, R Khanna, A Avni… - Proceedings of the …, 2023 - National Acad Sciences
Biomolecular condensates formed via phase separation of proteins and nucleic acids are
thought to perform a wide range of critical cellular functions by maintaining spatiotemporal …
thought to perform a wide range of critical cellular functions by maintaining spatiotemporal …
Protein misfolding and amyloid nucleation through liquid–liquid phase separation
Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …
[HTML][HTML] Liquid− liquid phase separation of tau: driving forces, regulation, and biological implications
P Li, J Chen, X Wang, Z Su, M Gao, Y Huang - Neurobiology of Disease, 2023 - Elsevier
The past 15 years have witnessed an explosion in the studies of biomolecular condensates
that are implicated in numerous biological processes and play vital roles in human health …
that are implicated in numerous biological processes and play vital roles in human health …
Challenges in studying the liquid-to-solid phase transitions of proteins using computer simulations
Abstract “Membraneless organelles,” also referred to as biomolecular condensates, perform
a variety of cellular functions and their dysregulation is implicated in cancer and …
a variety of cellular functions and their dysregulation is implicated in cancer and …
Electrostatic complementarity at the interface drives transient protein-protein interactions
Understanding the mechanisms driving bio-molecules binding and determining the resulting
complexes' stability is fundamental for the prediction of binding regions, which is the starting …
complexes' stability is fundamental for the prediction of binding regions, which is the starting …
Modulation of α-synuclein phase separation by biomolecules
LC Rodríguez, NN Foressi, MS Celej - Biochimica et Biophysica Acta (BBA) …, 2023 - Elsevier
Liquid-liquid phase separation (LLPS) is currently recognized as a common mechanism
involved in the regulation of a number of cellular functions. On the other hand, aberrant …
involved in the regulation of a number of cellular functions. On the other hand, aberrant …
Liquid–liquid phase separation in Alzheimer's disease
Q Fu, B Zhang, X Chen, L Chu - Journal of Molecular Medicine, 2024 - Springer
The pathological aggregation and misfolding of tau and amyloid-β play a key role in
Alzheimer's disease (AD). However, the underlying pathological mechanisms remain …
Alzheimer's disease (AD). However, the underlying pathological mechanisms remain …
VAMP2 regulates phase separation of α-synuclein
A Agarwal, A Chandran, F Raza, IM Ungureanu… - Nature Cell …, 2024 - nature.com
Abstract α-Synuclein (αSYN), a pivotal synaptic protein implicated in synucleinopathies such
as Parkinson's disease and Lewy body dementia, undergoes protein phase separation. We …
as Parkinson's disease and Lewy body dementia, undergoes protein phase separation. We …