The synucleins are a family of natively unfolded (or intrinsically unstructured) proteins
consisting of α-, β-, and γ-synuclein involved in neurodegenerative diseases and cancer …

Metabolic reactions within cells occur in various isolated compartments with or without
borders, the latter being known as membrane-less organelles (MLOs). The MLOs show …

Biomolecular condensates formed via phase separation of proteins and nucleic acids are
thought to perform a wide range of critical cellular functions by maintaining spatiotemporal …

Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …

The past 15 years have witnessed an explosion in the studies of biomolecular condensates
that are implicated in numerous biological processes and play vital roles in human health …

Abstract “Membraneless organelles,” also referred to as biomolecular condensates, perform
a variety of cellular functions and their dysregulation is implicated in cancer and …

Understanding the mechanisms driving bio-molecules binding and determining the resulting
complexes' stability is fundamental for the prediction of binding regions, which is the starting …

Liquid-liquid phase separation (LLPS) is currently recognized as a common mechanism
involved in the regulation of a number of cellular functions. On the other hand, aberrant …

The pathological aggregation and misfolding of tau and amyloid-β play a key role in
Alzheimer's disease (AD). However, the underlying pathological mechanisms remain …

Abstract α-Synuclein (αSYN), a pivotal synaptic protein implicated in synucleinopathies such
as Parkinson's disease and Lewy body dementia, undergoes protein phase separation. We …