Unveiling the power of gabapentin-loaded nanoceria with multiple therapeutic capabilities for the treatment of dry eye disease

CJ Yang, A Anand, CC Huang, JY Lai - ACS nano, 2023 - ACS Publications
Dry eye (DE) disease, which is primarily linked to aqueous deficiency, is an escalating
health issue worldwide, mainly due to the widespread use of electronic devices. The major …

Pirfenidone: a promising drug in ocular therapeutics

AC Bisen, S Agrawal, R Rayiti, SN Sanap… - Chemistry & …, 2024 - Wiley Online Library
Pirfenidone, initially indicated for lung fibrosis, has gone beyond its original purpose, and
shown promise in eye care. This detailed review tracks its evolution from lung treatment to …

Polypeptide-based systems: From synthesis to application in drug delivery

M Stepanova, A Nikiforov, T Tennikova… - Pharmaceutics, 2023 - mdpi.com
Synthetic polypeptides are biocompatible and biodegradable macromolecules whose
composition and architecture can vary over a wide range. Their unique ability to form …

Multienzyme‐Like Nanozyme Encapsulated Ocular Microneedles for Keratitis Treatment

S Liu, Q Bai, Y Jiang, Y Gao, Z Chen, L Shang… - Small, 2024 - Wiley Online Library
Keratitis, an inflammation of the cornea caused by bacterial or fungal infections, is one of the
leading causes of severe visual disability and blindness. Keratitis treatment requires both …

Development of injectable hyaluronic acid-based hydrogels with antioxidant activity for the treatment of corneal neovascularization

L Long, Z Ge, F Zhang, R Dong, L Yang, Z Chen… - Chemical Engineering …, 2023 - Elsevier
Corneal neovascularization (CNV) is a condition that can severely adversely affect corneal
transparency, culminating in visual disturbances and potential blindness. The need to …

Influence of the Synthesis Scheme of Nanocrystalline Cerium Oxide and Its Concentration on the Biological Activity of Cells Providing Wound Regeneration

EV Silina, VA Stupin, NE Manturova… - International Journal of …, 2023 - mdpi.com
In the ongoing search for practical uses of rare-earth metal nanoparticles, cerium dioxide
nanoparticles (nanoceria) have received special attention. The purpose of this research was …

Fucoidan-mediated targeted delivery of dasatinib-loaded nanoparticles amplifies apoptosis and endows cytotoxic potential in triple-negative breast cancer

BN Saren, S Mahajan, M Aalhate, R Kumar… - Colloids and Surfaces B …, 2024 - Elsevier
Dasatinib (DST) is a tyrosine kinase inhibitor with established antiproliferative activity in
Triple-negative breast cancer. Conventional treatment strategies with DST have several …

Topical Application of Cell-Penetrating Peptide Modified Anti-VEGF Drug Alleviated Choroidal Neovascularization in Mice

W Hu, W Cai, Y Wu, C Ren, D Yu, T Li… - International Journal …, 2024 - Taylor & Francis
Background Age-related macular degeneration (AMD) stands as the foremost cause of
irreversible central vision impairment, marked by choroidal neovascularization (CNV). The …

Combination of self-assembling system and N, O-carboxymethyl chitosan improves ocular residence of anti-glaucoma drug

V Kailasam, BN Kumara, KS Prasad, J Nirmal - European Journal of …, 2024 - Elsevier
Glaucoma is known to be one of the principal causes of vision loss due to elevated
intraocular pressure. Currently, latanoprost eye drops is used as first-line treatment for …

Two-dimensional ternary chalcogenide nanodots with spatially controlled catalytic activity for bacteria infected wound treatment

K Yang, M Ding, W Xiu, Y Zhang, H Dong… - Journal of Colloid and …, 2024 - Elsevier
Nanozymes hold great prospects for bacteria-infected wound management, yet the spatial
control of their catalytic activity in infected area and normal tissues remains mired by the …