Membrane proteins have diverse functions within cells and are well-established drug
targets. The advances in membrane protein structural biology have revealed drug and lipid …

Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by
resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor …

The use of agricultural neonicotinoid insecticides has sub-lethal chronic effects on bees that
are more prevalent than acute toxicity. Among these insecticides, thiacloprid, a commonly …

Receptors signal by switching between resting (C) and active (O) shapes ('gating') under the
influence of agonists. The receptor's maximum response depends on the difference in …

Introduction Accurate ranking of efficacies and potencies of agonists is essential in the
discovery of new selective agonists. For the purpose of system-independent ranking of …

Dinotefuran is a chiral neonicotinoid that is widely distributed in environmental matrices, but
its health risks to different organisms are poorly understood. This study investigated the …

Pentameric ligand-gated ion channel mediate signal transduction at chemical synapses by
transiting between resting and open states upon neurotransmitter binding. Here, we …

Molecular vibrations and quantum tunneling may link ligand binding to the function of
pharmacological receptors. The well‐established lock‐and‐key model explains a ligand's …

In allosteric proteins, identifying the pathways that signals take from allosteric ligand-binding
sites to enzyme active sites or binding pockets and interfaces remains challenging. This …

In this chapter we shall make the case that in the study of brain function–from computational
or clinical points of view–it is essential to take biological detail into consideration. In doing …