Gastric acidity is likely a key factor shaping the diversity and composition of microbial
communities found in the vertebrate gut. We conducted a systematic review to test the …

First-generation nanoparticles (NPs) have been clinically translated as pharmaceutical drug
delivery carriers for their ability to improve on drug tolerability, circulation half-life, and …

Anthocyanins, the natural red and purple colorants of berries, fruits, vegetables, and tubers,
improve carbohydrate metabolism and decrease the risk factors of metabolic disorders, but …

This article reviews the major physiological and physicochemical principles of the effect of
food and gastrointestinal (GI) pH on the absorption and bioavailability of oral drugs, and the …

Protein therapeutics have emerged as a significant role in treatment of a broad spectrum of
diseases, including cancer, metabolic disorders and autoimmune diseases. The efficacy of …

Anthocyanins are naturally occurring compounds widespread in plant-derived foodstuffs and
therefore abundant in human diet. There are evidences regarding the positive association of …

Mucus is a viscoelastic gel that traps pathogens and other foreign particles to limit their
penetration into the underlying epithelium. Dosage forms containing particle-based drug …

Dissolution tests are used for many purposes in the pharmaceutical industry: in the
development of new products, for quality control and, to assist with the determination of …

Purpose. In this paper we seek to verify the differences in dissolution behavior between
class I and class II drugs and to evaluate the suitability of two new physiologically based …

Simulation of gastrointestinal conditions is essential to adequately predict the in vivo
behavior of drug formulations. To reduce the size and number of human studies required to …