The extracellular matrix (ECM) surrounding cells is indispensable for regulating their
behavior. The dynamics of ECM signaling are tightly controlled throughout growth and …

Lung cancer is the leading cause of cancer-related mortality worldwide. Detectable driver
mutations have now changed the course of lung cancer treatment with the emergence of …

Endothelial to mesenchymal transition (EndMT) plays a major role during development, and
also contributes to several adult cardiovascular diseases. Importantly, mesenchymal cells …

Background: Cancer-associated fibroblasts (CAFs) are the most prominent cellular
components in gastric cancer (GC) stroma that contribute to GC progression, treatment …

Background Gallbladder cancer (GBC) is a leading cause of cancer-related death
worldwide, and its prognosis remains poor, with 5-year survival of approximately 5%. In this …

The study was aimed to screen out miRNAs with differential expression in hepatocellular
carcinoma (HCC), and to explore the influence of the expressions of these miRNAs and their …

Proteoglycans are a diverse group of molecules which are characterized by a central protein
backbone that is decorated with a variety of linear sulfated glycosaminoglycan side chains …

Abstract The Transforming Growth Factor-beta (TGFβ) pathway mediates a broad spectrum
of cellular processes and is involved in several diseases, including cancer. TGFβ has a dual …

The epithelial to mesenchymal transition (EMT) program is a crucial component in the
processes of morphogenesis and embryonic development. The transition of epithelial to …

The extracellular matrix (ECM) provides structural support for tissue architecture and is a
major effector of cell behavior during skin repair and inflammation. Macrophages are …