Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …

Although the histological changes seen in psoriasis have long been well characterized, the
underlying cellular and molecular mechanisms have only begun to be elucidated over the …

Systemic autoinflammatory diseases are driven by abnormal activation of innate immunity.
Herein we describe a new disease caused by high-penetrance heterozygous germline …

Using variants from the 1000 Genomes Project pilot European CEU dataset and data from
additional resequencing studies, we densely genotyped 183 non-HLA risk loci previously …

We performed a second-generation genome-wide association study of 4,533 individuals
with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs …

A20 (also known as TNFAIP3) is a potent anti-inflammatory signalling molecule that restricts
multiple intracellular signalling cascades. Recent studies in three general areas have …

Ulcerative colitis is a chronic, relapsing inflammatory condition of the gastrointestinal tract
with a complex genetic and environmental etiology. In an effort to identify genetic variation …

Autoinflammatory diseases are caused by defects in genes that regulate the innate
immunity. Recently, the scope of autoinflammation has been broadened to include diseases …

Nuclear factor (NF)-κB has an important role in immunity and inappropriate NF-κB activity
has been linked with many autoimmune and inflammatory diseases. Multiple mechanisms …

Epidemiology and candidate gene studies indicate a shared genetic basis for celiac disease
(CD) and rheumatoid arthritis (RA), but the extent of this sharing has not been systematically …