Human immunodeficiency virus type 1 (HIV-1) infection persists despite years of
antiretroviral therapy (ART). To remove the stigma and burden of chronic infection …

Today HIV infection cannot be cured due to the presence of a reservoir of latently infected
cells inducing a viral rebound upon treatment interruption. Hence, the latent reservoir is …

Toll-like receptors (TLRs) are a class of proteins that recognize pathogen-associated
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …

The discovery of the TLRs family and more precisely its functions opened a variety of gates
to modulate immunological host responses. TLRs 7/8 are located in the endosomal …

Innate immune sensors that detect nucleic acids are attractive targets for therapeutic
intervention because of their diverse roles in many disease processes. In detecting RNA and …

Background Treatment with vesatolimod, an investigational, oral, toll-like receptor 7 (TLR7)
agonist, leads to sustained viral remission in some non-human primates when combined …

Toll-like receptors (TLRs) are a family of pattern recognition receptors and part of the first
line of defense against invading microbes. In humans, we know of 10 different TLRs, which …

Combination antiretroviral therapy (ART) to treat human immunodeficiency virus (HIV)
infection has proven remarkably successful–for those who can access and afford it–yet HIV …

Latency reversal strategies for HIV cure using inhibitor of apoptosis protein (IAP) antagonists
(IAPi) induce unprecedented levels of latent reservoir expression without immunotoxicity …

Toll-like receptors (TLRs), as a family of pattern recognition receptors, play an important role
in the recognition of HIV-1 molecular structures by various cells of the innate immune …