The prevalence of diabetes is continuously increasing in the recent decades. Persistent
hyperglycemia, hyperinsulinemia and the subsequent oxidative stress result in diabetic …

The FOX family of transcription factors was originally identified in 1989, comprising the
FOXA to FOXS subfamilies. FOXO3, a well-known member of the FOXO subfamily, is widely …

Increasing studies have reported that intervertebral disc degeneration (IVDD) is the main
contributor and independent risk factor for low back pain (LBP), it would be, therefore …

Background Intestinal ischemia-reperfusion injury occurs in acute intestinal obstruction,
intussusception, acute mesenteric artery embolism, and other diseases and can lead to local …

Heart failure (HF) is a clinical syndrome characterized by typical symptoms that usually
occur at the end stage of various heart diseases and lead to death. Daidzein (DAI), an …

Background The nucleotide oligomerization domain (NOD)-like receptor family pyrin domain
containing 3 (NLRP3) in dorsal root ganglion (DRG) contributes to pain hypersensitivity in …

Numerous studies have shown that mitochondrial dysfunction manifested by increased
mitochondrial permeability transition pore (mPTP) opening and reactive oxygen species …

We have recently reported that honokiol (HKL), by activating mitochondrial SIRT3,
normalizes reactive oxygen species level and mitochondrial integrity in hippocampus of the …

An NAD+-dependent deacetylase called Sirtuin 3 (Sirt3) is involved in the metabolic
processes of the mitochondria, including energy generation, the tricarboxylic acid cycle, and …

Hyperlipidemia is considered a risk factor for cardiovascular and endocrine diseases.
However, effective approaches for treating this common metabolic disorder remain limited …