Human body is inhabited by vast number of microorganisms which form a complex
ecological community and influence the human physiology, in the aspect of both health and …

Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease whose incidence has
risen worldwide in recent years. Accumulating evidence shows that oxidative stress plays an …

Metabolite alteration has been associated with the pathogenesis of inflammatory bowel
disease (IBD), including colitis. Mannose, a natural bioactive monosaccharide that is …

Intestinal barrier integrity is a prerequisite for homeostasis of mucosal function, which is
balanced to maximise absorptive capacity, while maintaining efficient defensive reactions …

The pathogenesis of inflammatory bowel disease (IBD) is multifactorial with data suggesting
the role of a disturbed interaction between the gut and the intestinal microbiota. A defective …

Gasdermin D (GSDMD) induces pyroptosis via the pore-forming activity of its N-terminal
domain, cleaved by activated caspases associated with the release of IL-1β. Here, we report …

Abstract Berberine (BBR), a naturally-occurring isoquinoline alkaloid isolated from several
Chinese herbal medicines, has been widely used for the treatment of dysentery and colitis …

The regeneration of intestinal epithelial are maintained by continuous differentiation and
proliferation of intestinal stem cells (ISCs) under physiological and pathological conditions …

Maintaining a healthy gut environment is a prerequisite for sustainable animal production.
The gut plays a key role in the digestion and absorption of nutrients and constitutes an initial …

Although the gastrointestinal (GI) tract possesses intrinsic neural plexuses that allow a
significant degree of autonomy over GI functions, the central nervous system (CNS) provides …